Cell communication by tunneling nanotubes: Implications in disease and therapeutic applications.

Autor: Mittal R; Department of Otolaryngology, University of Miami-Miller School of Medicine, Miami, Florida., Karhu E; Department of Otolaryngology, University of Miami-Miller School of Medicine, Miami, Florida., Wang JS; Department of Otolaryngology, University of Miami-Miller School of Medicine, Miami, Florida., Delgado S; Department of Otolaryngology, University of Miami-Miller School of Medicine, Miami, Florida., Zukerman R; Department of Otolaryngology, University of Miami-Miller School of Medicine, Miami, Florida., Mittal J; Department of Otolaryngology, University of Miami-Miller School of Medicine, Miami, Florida., Jhaveri VM; Department of Otolaryngology, University of Miami-Miller School of Medicine, Miami, Florida.
Jazyk: angličtina
Zdroj: Journal of cellular physiology [J Cell Physiol] 2019 Feb; Vol. 234 (2), pp. 1130-1146. Date of Electronic Publication: 2018 Sep 12.
DOI: 10.1002/jcp.27072
Abstrakt: Intercellular communication is essential for the development and maintenance of multicellular organisms. Tunneling nanotubes (TNTs) are a recently recognized means of long and short distance communication between a wide variety of cell types. TNTs are transient filamentous membrane protrusions that connect cytoplasm of neighboring or distant cells. Cytoskeleton fiber-mediated transport of various cargoes occurs through these tubules. These cargoes range from small ions to whole organelles. TNTs have been shown to contribute not only to embryonic development and maintenance of homeostasis, but also to the spread of infectious particles and resistance to therapies. These functions in the development and progression of cancer and infectious disease have sparked increasing scrutiny of TNTs, as their contribution to disease progression lends them a promising therapeutic target. Herein, we summarize the current knowledge of TNT structure and formation as well as the role of TNTs in pathology, focusing on viral, prion, and malignant disease. We then discuss the therapeutic possibilities of TNTs in light of their varied functions. Despite recent progress in the growing field of TNT research, more studies are needed to precisely understand the role of TNTs in pathological conditions and to develop novel therapeutic strategies.
(© 2018 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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