Folic acid magnetic nanotheranostics for delivering doxorubicin: Toxicological and biocompatibility studies on Zebrafish embryo and larvae.
Autor: | Igartúa DE; Laboratorio de Biomembranas, Departamento de Ciencia y Tecnología, IMBICE-CONICET-CICPBA, Grupo de Biología Estructural y Biotecnología, Universidad Nacional de Quilmes, Roque Sáenz Peña 352, Buenos Aires, Argentina., Azcona PL; Instituto de Química del Sur (INQUISUR), Departamento de Química, CONICET, Universidad Nacional del Sur, Avenida Alem 1253, Buenos Aires 8000, Argentina., Martinez CS; Laboratorio de Biomembranas, Departamento de Ciencia y Tecnología, IMBICE-CONICET-CICPBA, Grupo de Biología Estructural y Biotecnología, Universidad Nacional de Quilmes, Roque Sáenz Peña 352, Buenos Aires, Argentina., Alonso SDV; Laboratorio de Biomembranas, Departamento de Ciencia y Tecnología, IMBICE-CONICET-CICPBA, Grupo de Biología Estructural y Biotecnología, Universidad Nacional de Quilmes, Roque Sáenz Peña 352, Buenos Aires, Argentina., Lassalle VL; Instituto de Química del Sur (INQUISUR), Departamento de Química, CONICET, Universidad Nacional del Sur, Avenida Alem 1253, Buenos Aires 8000, Argentina., Prieto MJ; Laboratorio de Biomembranas, Departamento de Ciencia y Tecnología, IMBICE-CONICET-CICPBA, Grupo de Biología Estructural y Biotecnología, Universidad Nacional de Quilmes, Roque Sáenz Peña 352, Buenos Aires, Argentina. Electronic address: jprieto@unq.edu.ar. |
---|---|
Jazyk: | angličtina |
Zdroj: | Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2018 Nov 01; Vol. 358, pp. 23-34. Date of Electronic Publication: 2018 Sep 08. |
DOI: | 10.1016/j.taap.2018.09.009 |
Abstrakt: | Doxorubicin (DOXO) is a chemotherapeutic agent widely used for the treatment of solid tumors and hematologic malignancies in both adults and children. However, DOXO causes short- and long-term cardiotoxicity and others undesirable side effects, such as nephrotoxicity and neurotoxicity. Magnetic nanoparticles (MNPs) allow the delivery of drugs specifically to target place, employing an external magnet. Moreover, they may act as contrast agents in MRI providing information on the diagnostic of diverse pathologies. In this way, two functions may be combined in a unique nanosystem known as theranostic. Also, the MNPs can be modified with folic acid (MNPs@FA) to increase the uptake by cancer cells that overexpress the FA receptors. In previous works, our collaborators obtained and characterized MNPs, MNPs@FA, and MNPs@FA@DOXO. It is essential to study the biosafety of nanotheranostic, and there is no published study of Fe (Copyright © 2018 Elsevier Inc. All rights reserved.) |
Databáze: | MEDLINE |
Externí odkaz: |