CDy14: a novel biofilm probe targeting exopolysaccharide Psl.

Autor: Kwon HY; Center for Self-assembly and Complexity, Institute for Basic Science (IBS), Pohang 37673, Republic of Korea., Kim JY, Lee JY, Yam JKH, Hultqvist LD, Xu W, Rybtke M, Tolker-Nielsen T, Kim JJ, Kang NY, Yang L, Park SJ, Givskov M, Chang YT
Jazyk: angličtina
Zdroj: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2018 Oct 18; Vol. 54 (84), pp. 11865-11868.
DOI: 10.1039/c8cc05544k
Abstrakt: Detection of biofilm bacteria would be an ideal method for the physicians to diagnose chronic bacterial infections directly, but there are few imaging probes available so far. Here, we report the development of a novel biofilm detecting fluorescent probe, CDy14, through an unbiased screening of a fluorescence library and elucidated its binding partner Psl, an exopolysaccharide of the biofilm.
Databáze: MEDLINE