| Autor: |
Stefani RM; 1 Department of Biomedical Engineering, Columbia University , New York, New York., Halder SS; 1 Department of Biomedical Engineering, Columbia University , New York, New York., Estell EG; 1 Department of Biomedical Engineering, Columbia University , New York, New York., Lee AJ; 1 Department of Biomedical Engineering, Columbia University , New York, New York., Silverstein AM; 1 Department of Biomedical Engineering, Columbia University , New York, New York., Sobczak E; 1 Department of Biomedical Engineering, Columbia University , New York, New York., Chahine NO; 1 Department of Biomedical Engineering, Columbia University , New York, New York.; 2 Department of Orthopedic Surgery, Columbia University , New York, New York., Ateshian GA; 1 Department of Biomedical Engineering, Columbia University , New York, New York.; 3 Department of Mechanical Engineering, Columbia University , New York, New York., Shah RP; 2 Department of Orthopedic Surgery, Columbia University , New York, New York., Hung CT; 1 Department of Biomedical Engineering, Columbia University , New York, New York. |
| Abstrakt: |
Impact Statement: The synovium envelops the diarthrodial joint and plays a key regulatory role in defining the composition of the synovial fluid through filtration and biosynthesis of critical boundary lubricants. Synovium changes often precede cartilage damage in osteoarthritis. We describe a novel in vitro tissue engineered model, validated against native synovium explants, to investigate the structure-function of synovium through quantitative solute transport measures. Synovium was evaluated in the presence of a proinflammatory cytokine, interleukin-1, or the clinically relevant corticosteroid, dexamethasone. We anticipate that a better understanding of synovium transport would support efforts to develop more effective strategies aimed at restoring joint health. |
