Understanding the endocannabinoid system as a modulator of the trigeminal pain response to concussion.

Autor:	Elliott MB; Department of Neurosurgery, Vickie & Jack Farber Institute for Neuroscience Thomas Jefferson University, PA 19107, USA.; Department of Neurosurgery, Vickie & Jack Farber Institute for Neuroscience Thomas Jefferson University, PA 19107, USA., Ward SJ; Department of Pharmacology, Lewis Katz School of Medicine, Temple University, PA 19140, USA.; Department of Pharmacology, Lewis Katz School of Medicine, Temple University, PA 19140, USA., Abood ME; Department of Anatomy & Cell Biology, Lewis Katz School of Medicine, Temple University, PA 19140, USA.; Department of Anatomy & Cell Biology, Lewis Katz School of Medicine, Temple University, PA 19140, USA., Tuma RF; Department of Physiology Lewis Katz School of Medicine, Temple University, PA 19140, USA.; Department of Physiology Lewis Katz School of Medicine, Temple University, PA 19140, USA., Jallo JI; Department of Neurosurgery, Vickie & Jack Farber Institute for Neuroscience Thomas Jefferson University, PA 19107, USA.; Department of Neurosurgery, Vickie & Jack Farber Institute for Neuroscience Thomas Jefferson University, PA 19107, USA.
Jazyk:	angličtina
Zdroj:	Concussion (London, England) [Concussion] 2017 Oct 04; Vol. 2 (4), pp. CNC49. Date of Electronic Publication: 2017 Oct 04 (Print Publication: 2017).
DOI:	10.2217/cnc-2017-0010
Abstrakt:	Post-traumatic headache is the most common symptom of postconcussion syndrome and becomes a chronic neurological disorder in a substantial proportion of patients. This review provides a brief overview of the epidemiology of postconcussion headache, research models used to study this disorder, as well as the proposed mechanisms. An objective of this review is to enhance the understanding of how the endogenous cannabinoid system is essential for maintaining the balance of the CNS and regulating inflammation after injury, and in turn making the endocannabinoid system a potential modulator of the trigeminal response to concussion. The review describes the role of endocannabinoid modulation of pain and the potential for use of phytocannabinoids to treat pain, migraine and concussion. Competing Interests: Financial & competing interests disclosure The authors thank the Department of Neurosurgery, the Jefferson Headache Center, and Vickie and Jack Farber Institute for their continued support. Related research support is provided from DoD W81XWH-14-1-0594 to MB Elliott and P30 DA013429 to ME Abood, SJ Ward and RF Tuma. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.
Databáze:	MEDLINE
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