Computer-assisted Curie scoring for metaiodobenzylguanidine (MIBG) scans in patients with neuroblastoma.

Autor: Sokol EA; Department of Pediatrics, The University of Chicago, Chicago, Illinois., Engelmann R; Department of Radiology, The University of Chicago, Chicago, Illinois., Kang W; Center for Research Informatics, The University of Chicago, Chicago, Illinois., Pinto N; Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington., Starkey A; Department of Radiology, The University of Chicago, Chicago, Illinois., Lai H; Department of Radiology, Children's Hospital of Orange County, Orange, California., Nadel H; Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada., Shulkin BL; Department of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, Tennessee., Pu Y; Department of Radiology, The University of Chicago, Chicago, Illinois., Appelbaum D; Department of Radiology, The University of Chicago, Chicago, Illinois., Yanik GA; Department of Pediatrics, University of Michigan School of Medicine, Ann Arbor, Michigan., Cohn SL; Department of Pediatrics, The University of Chicago, Chicago, Illinois., Armato SG 3rd; Department of Radiology, The University of Chicago, Chicago, Illinois., Volchenboum S; Department of Pediatrics, The University of Chicago, Chicago, Illinois.; Center for Research Informatics, The University of Chicago, Chicago, Illinois.
Jazyk: angličtina
Zdroj: Pediatric blood & cancer [Pediatr Blood Cancer] 2018 Dec; Vol. 65 (12), pp. e27417. Date of Electronic Publication: 2018 Sep 10.
DOI: 10.1002/pbc.27417
Abstrakt: Background: Radiolabeled metaiodobenzylguanidine (MIBG) is sensitive and specific for detecting neuroblastoma. The extent of MIBG-avid disease is assessed using Curie scores. Although Curie scoring is prognostic in patients with high-risk neuroblastoma, there is no standardized method to assess the response of specific sites of disease over time. The goal of this study was to develop approaches for Curie scoring to facilitate the calculation of scores and comparison of specific sites on serial scans.
Procedure: We designed three semiautomated methods for determining Curie scores, each with increasing degrees of computer assistance. Method A was based on visual assessment and tallying of MIBG-avid lesions. For method B, scores were tabulated from a schematic that associated anatomic regions to MIBG-positive lesions. For method C, an anatomic mesh was used to mark MIBG-positive lesions with automatic assignment and tallying of scores. Five imaging physicians experienced in MIBG interpretation scored 38 scans using each method, and the feasibility and utility of the methods were assessed using surveys.
Results: There was good reliability between methods and observers. The user-interface methods required 57 to 110 seconds longer than the visual method. Imaging physicians indicated that it was useful that methods B and C enabled tracking of lesions. Imaging physicians preferred method B to method C because of its efficiency.
Conclusions: We demonstrate the feasibility of semiautomated approaches for Curie score calculation. Although more time was needed for strategies B and C, the ability to track and document individual MIBG-positive lesions over time is a strength of these methods.
(© 2018 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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