Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories.

Autor:	Mitchell SJ; Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Bernier M; Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Mattison JA; Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Aon MA; Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA; Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Kaiser TA; Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Anson RM; Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA; Biology Department, Community College of Baltimore County - Dundalk, Baltimore, MD 21222, USA., Ikeno Y; Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245-3207, USA., Anderson RM; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA; Geriatric Research, Education, and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA., Ingram DK; Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA., de Cabo R; Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA. Electronic address: decabora@grc.nia.nih.gov.
Jazyk:	angličtina
Zdroj:	Cell metabolism [Cell Metab] 2019 Jan 08; Vol. 29 (1), pp. 221-228.e3. Date of Electronic Publication: 2018 Sep 06.
DOI:	10.1016/j.cmet.2018.08.011
Abstrakt:	The importance of dietary composition and feeding patterns in aging remains largely unexplored, but was implicated recently in two prominent nonhuman primate studies. Here, we directly compare in mice the two diets used in the primate studies focusing on three paradigms: ad libitum (AL), 30% calorie restriction (CR), and single-meal feeding (MF), which accounts for differences in energy density and caloric intake consumed by the AL mice. MF and CR regimes enhanced longevity regardless of diet composition, which alone had no significant impact within feeding regimens. Like CR animals, MF mice ate quickly, imposing periods of extended daily fasting on themselves that produced significant improvements in morbidity and mortality compared with AL. These health and survival benefits conferred by periods of extended daily fasting, independent of dietary composition, have major implications for human health and clinical applicability. (Published by Elsevier Inc.)
Databáze:	MEDLINE
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