Global gray matter morphometry differences between children with reading disability, ADHD, and comorbid reading disability/ADHD.

Autor: Jagger-Rickels AC; Southern Illinois University, Carbondale, United States., Kibby MY; Southern Illinois University, Carbondale, United States. Electronic address: mkibby@siu.edu., Constance JM; Southern Illinois University, Carbondale, United States.
Jazyk: angličtina
Zdroj: Brain and language [Brain Lang] 2018 Oct; Vol. 185, pp. 54-66. Date of Electronic Publication: 2018 Sep 04.
DOI: 10.1016/j.bandl.2018.08.004
Abstrakt: Extensive, yet disparate, research exists elucidating structural anomalies in individuals with Reading Disability (RD) or ADHD. Despite ADHD and RD being highly comorbid, minimal research has attempted to determine shared patterns of morphometry between these disorders. In addition, there is no published research examining the morphometry of comorbid RD and ADHD (RD/ADHD). Hence, we conducted voxel-based morphometry on the MRI scans of 106 children, ages 8-12 years, with RD, ADHD, or RD/ADHD, and typically developing controls. We found right caudate and superior frontal regions in both RD and ADHD, along with areas specific to RD and to ADHD that are consistent with current theories on these disorders. Perhaps most importantly, we found a potential neurobiological substrate for RD/ADHD. Further, our findings illustrate both shared and specific contributors to RD/ADHD, supporting two current theories on the comorbidity of RD and ADHD, thereby facilitating future work on potential etiologies of RD/ADHD.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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