A Comparative Analysis of Survival and Funding Discrepancies in Cancers With High Mortality.

Autor:	Hall BR; Department of Surgery, Division of Surgical Oncology, University of Nebraska Medical Center, Omaha, NE.; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE., Cannon A; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE., Atri P; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE., Wichman CS; College of Public Health, Department of Biostatistics, University of Nebraska Medical Center, Omaha, NE., Smith LM; College of Public Health, Department of Biostatistics, University of Nebraska Medical Center, Omaha, NE., Kumar S; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE., Batra SK; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE., Wang H; College of Public Health, Department of Biostatistics, University of Nebraska Medical Center, Omaha, NE., Ganti AK; Department of Internal Medicine, Division of Hematology and Oncology, University of Nebraska Medical Center, Omaha, NE.; Department of Internal Medicine, Division of Hematology and Oncology, VA Nebraska-Western Iowa Health Care System, Omaha, NE., Sasson AR; Department of Surgery, Division of Surgical Oncology, Stony Brook School of Medicine, Stony Brooke, NY., Are C; Department of Surgery, Division of Surgical Oncology, University of Nebraska Medical Center, Omaha, NE.
Jazyk:	angličtina
Zdroj:	Annals of surgery [Ann Surg] 2020 Feb; Vol. 271 (2), pp. 296-302.
DOI:	10.1097/SLA.0000000000003042
Abstrakt:	Objective: Comparative analyses of survival and funding statistics in cancers with high mortality were performed to quantify discrepancies and identify areas for intervention. Background: Discrepancies in research funding may contribute to stagnant survival rates in pancreatic ductal adenocarcinoma (PDAC). Methods: The Surveillance, Epidemiology, and End Results database was queried for survival statistics. Funding data were obtained from the National Cancer Institute (NCI). Clinical trial data were obtained from www.clinicaltrials.gov. Cancers with high mortality were included for analyses. Results: Since 1997, PDAC has received lesser funding ($1.41 billion) than other cancers such as breast ($10.52 billion), prostate ($4.93 billion), lung ($4.80 billion), and colorectal ($4.50 billion). Similarly, fewer clinical trials have been completed in PDAC (n = 608) compared with breast (n = 1904), lung (n = 1629), colorectal (n = 1080), and prostate (n = 1055) cancer. Despite this, since 1997, dollars invested in PDAC research produced a greater return on investment with regards to 5-year overall survival (5Y-OS) compared with breast, prostate, uterine, and ovarian cancer. Incremental cost-effectiveness analysis demonstrates that millions (liver, non-Hodgkin lymphoma, and melanoma) and billions (colorectal and lung) of dollars were required for each additional 1% increase in 5Y-OS compared with PDAC. Funding of research towards early diagnosis of PDAC has decreased by 19% since 2007. For nearly all cancers, treatment-related research receives the highest percentage of NCI funding. Conclusions: Funding of PDAC research is significantly less than other cancers, despite its higher mortality and greater potential to improve 5Y-OS. Increased awareness and lobbying are required to increase funding, promote research, and improve survival.
Databáze:	MEDLINE
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