| Autor: |
Tabakov VY, Veiko NN, Chestkov VV, Kostyuk SV |
| Jazyk: |
English; Russian |
| Zdroj: |
Tsitologiia [Tsitologiia] 2016; Vol. 58 (12), pp. 924-9. |
| Abstrakt: |
At present research we have demonstrated the link between introducing of low molecular weight RSH-antioxidants (N-acetylcysteine, glutathione) into serum-free medium composition, reactive oxygen species (ROS) generation and mouse myeloma SP2/0-SF cells proliferative activity. The presence of these compounds in the medium changed the pattern of ROS-activity in cells by concentration-dependent manner, and affected their proliferative characteristics. The optimal value of the proliferative activity was related to 0.2 mM for both thyols and not depended from the thyol-compound nature. Further increasing up from the found concentration optimum lead to growth inhibition with different expression for N-acetylcysteine and glutathione. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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