The Hepatoprotective Effect of Jaboticaba Peel Powder in a Rat Model of Type 2 Diabetes Mellitus Involves the Modulation of Thiol/Disulfide Redox State through the Upregulation of Glutathione Synthesis.

Autor: Quatrin A; Graduate Program Food Science and Technology, Centre of Rural Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil.; Integrated Centre for Laboratory Analysis Development (NIDAL), Department of Food Technology and Science, Centre of Rural Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil., Conte L; Integrated Centre for Laboratory Analysis Development (NIDAL), Department of Food Technology and Science, Centre of Rural Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil.; Graduate Program on Pharmacology, Centre of Health Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil., da Silva DT; Integrated Centre for Laboratory Analysis Development (NIDAL), Department of Food Technology and Science, Centre of Rural Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil.; Graduate Program on Pharmacology, Centre of Health Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil., Figueiredo CG; Integrated Centre for Laboratory Analysis Development (NIDAL), Department of Food Technology and Science, Centre of Rural Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil., Somacal S; Integrated Centre for Laboratory Analysis Development (NIDAL), Department of Food Technology and Science, Centre of Rural Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil., Roehrs M; Integrated Centre for Laboratory Analysis Development (NIDAL), Department of Food Technology and Science, Centre of Rural Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil., Teixeira CF; Biogenomic Laboratory, Department of Morphology, Centre of Health Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil., Barbisan F; Graduate Program on Pharmacology, Centre of Health Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil.; Biogenomic Laboratory, Department of Morphology, Centre of Health Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil., Augusti PR; Department of Food Science, Federal University of Rio Grande do Sul, 91501-970 Porto Alegre, RS, Brazil., Maróstica Júnior MR; School of Food Engineering, University of Campinas, 13083-862 Campinas, SP, Brazil., da Cruz IBM; Department of Food Science, Federal University of Rio Grande do Sul, 91501-970 Porto Alegre, RS, Brazil., Emanuelli T; Graduate Program Food Science and Technology, Centre of Rural Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil.; Integrated Centre for Laboratory Analysis Development (NIDAL), Department of Food Technology and Science, Centre of Rural Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil.
Jazyk: angličtina
Zdroj: Journal of nutrition and metabolism [J Nutr Metab] 2018 Aug 01; Vol. 2018, pp. 9794629. Date of Electronic Publication: 2018 Aug 01 (Print Publication: 2018).
DOI: 10.1155/2018/9794629
Abstrakt: Jaboticaba peel powder (JPP) is rich in bioactive compounds, mainly soluble and insoluble polyphenols with great antioxidant properties. The aim of this study is to evaluate the effects of JPP supplementation on the oxidative stress and hepatic damage in a rat model of type 2 diabetes mellitus (T2DM). Diabetic rats received vehicle or JPP at 2.7 (JPP-I), 5.4 (JPP-II), or 10.8 (JPP-III) g/L in drinking water during 8 weeks. JPP-III attenuated hyperglycaemia and dyslipidemia increased by 86% the liver content of nonprotein thiol groups and by 90% the GSH/GSSG ratio by activating glutathione synthesis. Accordingly, JPP supplementation prevented the loss of activity of the sulfhydryl-dependent enzyme δ -aminolaevulinic acid dehydratase and attenuated hepatic injury assessed by the reduction of serum aspartate aminotransferase activity and liver hypertrophy. Our results support that JPP supplementation to T2DM rats decreases hepatic damage most likely by increasing glutathione synthesis and modulating the thiol/disulfide redox balance.
Databáze: MEDLINE
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