Lysosomes nor Mice Move Forward without Borcs7.

Autor: Joshi U; Cellular Protein Chemistry, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands., Houwman JA; Cellular Protein Chemistry, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands., van der Sluijs P; Cellular Protein Chemistry, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands. Electronic address: p.vandersluijs1@uu.nl.
Jazyk: angličtina
Zdroj: Trends in cell biology [Trends Cell Biol] 2018 Oct; Vol. 28 (10), pp. 761-763. Date of Electronic Publication: 2018 Sep 02.
DOI: 10.1016/j.tcb.2018.08.002
Abstrakt: Lysosome function and position in the cytoplasm depends on the BORCS machinery, which tethers lysosomes to the kinesin microtubule motor. A recent paper of Snouwaert et al. in Cell Reports characterizes a mouse with a spontaneous mutation in the Borcs7 subunit, which causes axonal dystrophy and impaired motor function.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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