Serum neuron-specific enolase, a marker of neuronal injury, increases after catheter ablation of atrial fibrillation.

Autor:	Acibuca A; 1 Department of Cardiology, Ankara University School of Medicine, Ankara, Turkey., Vurgun VK; 1 Department of Cardiology, Ankara University School of Medicine, Ankara, Turkey., Gerede DM; 1 Department of Cardiology, Ankara University School of Medicine, Ankara, Turkey., Altin AT; 1 Department of Cardiology, Ankara University School of Medicine, Ankara, Turkey., Gul IS; 2 Department of Neurology, Ankara University School of Medicine, Ankara, Turkey., Candemir B; 1 Department of Cardiology, Ankara University School of Medicine, Ankara, Turkey., Isikay Togay C; 2 Department of Neurology, Ankara University School of Medicine, Ankara, Turkey., Kilickap M; 1 Department of Cardiology, Ankara University School of Medicine, Ankara, Turkey., Akyurek O; 1 Department of Cardiology, Ankara University School of Medicine, Ankara, Turkey.
Jazyk:	angličtina
Zdroj:	The Journal of international medical research [J Int Med Res] 2018 Nov; Vol. 46 (11), pp. 4518-4526. Date of Electronic Publication: 2018 Sep 05.
DOI:	10.1177/0300060518767768
Abstrakt:	Objective: Catheter ablation of atrial fibrillation (AF) can lead to thromboembolic complications, especially stroke. We measured the periprocedural serum neuron-specific enolase (NSE) level, which is a biomarker of neuronal injury, after ablation of AF. Methods: Forty-three patients with paroxysmal AF were prospectively enrolled before radiofrequency ablation. A neurological examination was performed before and after the procedure. The serum NSE level was determined before and at the end of the procedure and at 2, 24, and 48 h after the procedure. Results: No patients developed new neurological deficits. However, the median (interquartile range) NSE level increased after ablation from 6.7 (3.87) ng/mL at baseline to 11.48 (5.3) ng/mL at 24 h postoperatively. The NSE level exceed the upper reference limit of normal (17 ng/mL) in 14 patients (33%), and these patients were found to have a larger left atrium. Conclusions: Serum NSE increased in most of the patients undergoing ablation for AF, and it exceeded the normal limit in one-third of the patients. Although NSE is a biomarker of neuronal injury, the clinical importance of this increase after AF ablation and its relationship with the left atrial diameter should be evaluated in a longitudinal study.
Databáze:	MEDLINE
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