Fiber-reinforced colloidal gels as injectable and moldable biomaterials for regenerative medicine.

Autor: Diba M; Department of Biomaterials, Radboud University Medical Center, Philips van Leydenlaan 25, 6525 EX Nijmegen, the Netherlands., Polini A; Department of Biomaterials, Radboud University Medical Center, Philips van Leydenlaan 25, 6525 EX Nijmegen, the Netherlands., Petre DG; Department of Biomaterials, Radboud University Medical Center, Philips van Leydenlaan 25, 6525 EX Nijmegen, the Netherlands., Zhang Y; Department of Biomaterials, Radboud University Medical Center, Philips van Leydenlaan 25, 6525 EX Nijmegen, the Netherlands., Leeuwenburgh SCG; Department of Biomaterials, Radboud University Medical Center, Philips van Leydenlaan 25, 6525 EX Nijmegen, the Netherlands. Electronic address: Sander.Leeuwenburgh@radboudumc.nl.
Jazyk: angličtina
Zdroj: Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2018 Nov 01; Vol. 92, pp. 143-150. Date of Electronic Publication: 2018 Jun 19.
DOI: 10.1016/j.msec.2018.06.038
Abstrakt: Hydrogels are the preferred material choice for various strategies in regenerative medicine. Nevertheless, due to their high water content and soft nature, these materials are often mechanically weak, which limits their applicability. This study demonstrates mechanical reinforcement of colloidal gels at microscale using discrete polyester fibers, as confirmed by rheological, compression and nanoindentation tests. This reinforcement strategy results in injectable and moldable colloidal gels with improved mechanical performance. The fully organic gels presented here are cytocompatible and can maintain their mechanical integrity under physiological conditions. Consequently, these gels exhibit a strong potential for applications in tissue engineering and regenerative medicine.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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