First trimester placental vascularization and angiogenetic factors are associated with adverse pregnancy outcome.

Autor: Leijnse JEW; Department of Obstetrics, Wilhelmina Children's Hospital, University Medical Centre Utrecht, 3508 GA Utrecht, The Netherlands. Electronic address: jleijnse@rkz.nl., de Heus R; Department of Obstetrics, Wilhelmina Children's Hospital, University Medical Centre Utrecht, 3508 GA Utrecht, The Netherlands., de Jager W; Department of Pediatric Immunology, Laboratory of Translational Immunology and Multiplex Core Facility, Wilhelmina Children's Hospital, University Medical Centre Utrecht, 3584 CX Utrecht, The Netherlands., Rodenburg W; National Institute for Public Health and Environment (RIVM), 3721 MA Bilthoven, The Netherlands., Peeters LLH; Department of Obstetrics, Wilhelmina Children's Hospital, University Medical Centre Utrecht, 3508 GA Utrecht, The Netherlands., Franx A; Department of Obstetrics, Wilhelmina Children's Hospital, University Medical Centre Utrecht, 3508 GA Utrecht, The Netherlands., Eijkelkamp N; Laboratory of Neuroimmunology and Developmental Origins of Disease (NIDOD), Wilhelmina Children's Hospital, University Medical Centre Utrecht, 3584 EA Utrecht, The Netherlands.
Jazyk: angličtina
Zdroj: Pregnancy hypertension [Pregnancy Hypertens] 2018 Jul; Vol. 13, pp. 87-94. Date of Electronic Publication: 2018 Apr 11.
DOI: 10.1016/j.preghy.2018.04.008
Abstrakt: Background: Hypertensive disorders, fetal growth restriction and preterm birth are major obstetrical complications and are related to impaired placentation. Early identification of impaired placentation can advance clinical care by preventing or postpone adverse pregnancy outcome.
Objectives: Determine whether sonographic assessed placental vascular development and concomitant changes in inflammation- and/or angiogenesis-related serumproteins differ in the first trimester between uncomplicated pregnancies and pregnancies with adverse outcome.
Study Design: This prospective longitudinal study defines adverse pregnancy outcome as conditions associated with impaired placentation; fetal growth restriction, hypertensive disorder, preterm birth and placental abruption. The vascularization index, flow index, vascularization flow index and placental volume were determined at 8, 10 and 12 weeks pregnancy from 64 women using 3D power Doppler. Serum levels were analyzed for Angiopoetin-1 and -2, Leptin, VEGF-R, VEGF, and EGF.
Results: The vascularization index and vascular flow index increased in uneventful pregnancies with almost 50% between 8 and 12 weeks, resulting in a ∼50% higher vascularization index at 12 weeks compared to women with an adverse pregnancy outcome. Women with an adverse pregnancy outcome (n = 13) had significantly lower indices and placental volumes at all time points measured and these indices did not increase between 8 and 12 weeks. Reduced vascular development was associated with increased Angiopoietin-1 levels at 8 and 12 weeks and increased Leptin levels at 8 weeks.
Conclusions: Pregnancies with an adverse outcome caused by conditions associated with impaired placentation differ from uneventful pregnancies in having reduced placental vascularization accompanied by elevated circulating levels of Angiopoietin-1 and Leptin already in the first trimester.
(Copyright © 2018 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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