Diet during Pregnancy and Infancy and the Infant Intestinal Microbiome.

Autor: Savage JH; Vertex Pharmaceuticals, Boston, MA., Lee-Sarwar KA; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA., Sordillo JE; Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care, Boston, MA., Lange NE; Harvard Medical School, Boston, MA; Division of Pulmonary and Critical Care Medicine, Beth Israel Deaconess Medical Center, Boston, MA., Zhou Y; Department of Medicine, University of Connecticut School of Medicine., O'Connor GT; Boston University School of Medicine, Boston, MA., Sandel M; Boston University School of Medicine, Boston, MA., Bacharier LB; Division of Allergy, Immunology, and Pulmonary Medicine, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, MO., Zeiger R; Kaiser Permanente Southern California Region, San Diego, CA., Sodergren E; Jackson Laboratory for Genomic Medicine, Farmington, CT., Weinstock GM; Jackson Laboratory for Genomic Medicine, Farmington, CT., Gold DR; Harvard Medical School, Boston, MA; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA., Weiss ST; Harvard Medical School, Boston, MA; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA., Litonjua AA; Division of Pediatric Pulmonary Medicine, Golisano Children's Hospital, University of Rochester Medical Center, Rochester, NY.
Jazyk: angličtina
Zdroj: The Journal of pediatrics [J Pediatr] 2018 Dec; Vol. 203, pp. 47-54.e4. Date of Electronic Publication: 2018 Aug 30.
DOI: 10.1016/j.jpeds.2018.07.066
Abstrakt: Objectives: To determine the association between diet during pregnancy and infancy, including breastfeeding vs formula feeding, solid food introduction, and the infant intestinal microbiome.
Study Design: Infants participating in the Vitamin D Antenatal Asthma Reduction Trial were included in this study (n = 323). Maternal and infant diets were assessed by questionnaire. Infant stool samples were collected at age 3-6 months. Stool sequencing was performed using the Roche 454 platform. Analyses were stratified by race/ethnicity.
Results: Breastfeeding, compared with formula feeding, was independently associated with infant intestinal microbial diversity. Breastfeeding also had the most consistent associations with individual taxa that have been previously linked to early-life diet and health outcomes (eg, Bifidobacterium). Maternal diet during pregnancy and solid food introduction were less associated with the infant gut microbiome than breastfeeding status. We found evidence of a possible interaction between breastfeeding and child race/ethnicity on microbial composition.
Conclusions: Breastfeeding vs formula feeding is the dietary factor that is most consistently independently associated with the infant intestinal microbiome. The relationship between breastfeeding status and intestinal microbiome composition varies by child race/ethnicity. Future studies will need to investigate factors, including genomic factors, which may influence the response of the microbiome to diet.
Trial Registration: ClinicalTrials.gov: NCT00920621.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: