Predicting the effect of ozone on vegetation via linear non-threshold (LNT), threshold and hormetic dose-response models.

Autor: Agathokleous E; Hokkaido Research Center, Forestry and Forest Products Research Institute (FFPRI), Forest Research and Management Organization, 7 Hitsujigaoka, Sapporo, Hokkaido 062-8516, Japan; Research Faculty of Agriculture, Hokkaido University, Kita 9 Nishi 9, Sapporo, Hokkaido 060-8589, Japan. Electronic address: evgenios@affrc.go.jp., Belz RG; University of Hohenheim, Agroecology Unit, Hans-Ruthenberg Institute, 70593 Stuttgart, Germany. Electronic address: regina.belz@uni-hohenheim.de., Calatayud V; Instituto Universitario CEAM-UMH, Charles R. Darwin 14, Parc Tecnològic, 46980 Paterna, Valencia, Spain. Electronic address: vicent@ceam.es., De Marco A; Italian National Agency for New Technologies, Energy and the Environment (ENEA), C.R. Casaccia, S. Maria di Galeria, Rome 00123, Italy. Electronic address: alessandra.demarco@enea.it., Hoshika Y; National Council of Research, Via Madonna del Piano 10, Sesto Fiorentino, Florence 50019, Italy. Electronic address: yasutomo.hoshika@ipsp.cnr.it., Kitao M; Hokkaido Research Center, Forestry and Forest Products Research Institute (FFPRI), Forest Research and Management Organization, 7 Hitsujigaoka, Sapporo, Hokkaido 062-8516, Japan. Electronic address: kitao@ffpri.affrc.go.jp., Saitanis CJ; Lab of Ecology and Environmental Science, Agricultural University of Athens, Iera Odos 75, Athens 11855, Greece. Electronic address: saitanis@aua.gr., Sicard P; ARGANS, 260 route du Pin Montard, BP 234, Sophia Antipolis Cedex 06904, France. Electronic address: psicard@argans.eu., Paoletti E; National Council of Research, Via Madonna del Piano 10, Sesto Fiorentino, Florence 50019, Italy. Electronic address: elena.paoletti@cnr.it., Calabrese EJ; Department of Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA. Electronic address: edwardc@schoolph.umass.edu.
Jazyk: angličtina
Zdroj: The Science of the total environment [Sci Total Environ] 2019 Feb 01; Vol. 649, pp. 61-74. Date of Electronic Publication: 2018 Aug 22.
DOI: 10.1016/j.scitotenv.2018.08.264
Abstrakt: The nature of the dose-response relationship in the low dose zone and how this concept may be used by regulatory agencies for science-based policy guidance and risk assessment practices are addressed here by using the effects of surface ozone (O 3 ) on plants as a key example for dynamic ecosystems sustainability. This paper evaluates the current use of the linear non-threshold (LNT) dose-response model for O 3 . The LNT model has been typically applied in limited field studies which measured damage from high exposures, and used to estimate responses to lower concentrations. This risk assessment strategy ignores the possibility of biological acclimation to low doses of stressor agents. The upregulation of adaptive responses by low O 3 concentrations typically yields pleiotropic responses, with some induced endpoints displaying hormetic-like biphasic dose-response relationships. Such observations recognize the need for risk assessment flexibility depending upon the endpoints measured, background responses, as well as possible dose-time compensatory responses. Regulatory modeling strategies would be significantly improved by the adoption of the hormetic dose response as a formal/routine risk assessment option based on its substantial support within the literature, capacity to describe the entire dose-response continuum, documented explanatory dose-dependent mechanisms, and flexibility to default to a threshold feature when background responses preclude application of biphasic dose responses.
Capsule: The processes of ozone hazard and risk assessment can be enhanced by incorporating hormesis into their principles and practices.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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