Using structural MRI to identify bipolar disorders - 13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Group.

Autor: Nunes A; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.; Faculty of Computer Science, Dalhousie University, Halifax, Nova Scotia, Canada., Schnack HG; Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Ching CRK; Interdepartmental Neuroscience Program, University of California, Los Angeles, CA, USA.; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA., Agartz I; NORMENT KG Jebsen Centre, University of Oslo, Oslo, Norway.; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden., Akudjedu TN; Centre for Neuroimaging and Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland., Alda M; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada., Alnæs D; NORMENT KG Jebsen Centre, University of Oslo, Oslo, Norway.; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Alonso-Lana S; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain., Bauer J; Institute of Clinical Radiology, Medical Faculty - University of Muenster - and University Hospital Muenster, Muenster, Germany., Baune BT; Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Parkville, VIC, Australia., Bøen E; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway., Bonnin CDM; Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain., Busatto GF; Laboratory of Psychiatric Neuroimaging (LIM-21), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.; Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of São Paulo, São Paulo, Brazil., Canales-Rodríguez EJ; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain., Cannon DM; Centre for Neuroimaging and Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland., Caseras X; MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Chaim-Avancini TM; Laboratory of Psychiatric Neuroimaging (LIM-21), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.; Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of São Paulo, São Paulo, Brazil., Dannlowski U; Department of Psychiatry, University of Münster, Münster, Germany., Díaz-Zuluaga AM; Research Group in Psychiatry, Department of Psychiatry, Faculty of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia., Dietsche B; Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany., Doan NT; NORMENT KG Jebsen Centre, University of Oslo, Oslo, Norway.; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Duchesnay E; NeuroSpin, CEA, Paris-Saclay, Gif sur Yvette, France., Elvsåshagen T; NORMENT KG Jebsen Centre, University of Oslo, Oslo, Norway.; Department of Neurology, Oslo Universisty Hospital, Oslo, Norway., Emden D; Department of Psychiatry, University of Münster, Münster, Germany., Eyler LT; Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.; Desert-Pacific Mental Illness Research, Education, and Clinical Center, VA San Diego Healthcare System, La Jolla, CA, USA., Fatjó-Vilas M; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.; Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain., Favre P; NeuroSpin, CEA, Paris-Saclay, Gif sur Yvette, France., Foley SF; Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, UK., Fullerton JM; Neuroscience Research Australia, Sydney, NSW, Australia.; School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia., Glahn DC; Department of Psychiatry, Yale University, New Haven, CT, USA.; Olin Neuropsychiatric Research Center, Institute of Living, Hartford Hospital, Hartford, CT, USA., Goikolea JM; Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain., Grotegerd D; Department of Psychiatry, University of Münster, Münster, Germany., Hahn T; Department of Psychiatry, University of Münster, Münster, Germany., Henry C; Institut Pasteur, Unité Perception et Mémoire, Paris, France., Hibar DP; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA., Houenou J; NeuroSpin, CEA, Paris-Saclay, Gif sur Yvette, France.; INSERM U955 Team 15 'Translational Psychiatry', University Paris East, APHP, CHU Mondor, Fondation FondaMental, Créteil, France., Howells FM; Neuroscience Institute, University of Cape Town, Cape Town, South Africa.; Translational Neuroscience Group, Department of Psychiatry and Mental Health, Cape Town, South Africa., Jahanshad N; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA., Kaufmann T; NORMENT KG Jebsen Centre, University of Oslo, Oslo, Norway.; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Kenney J; Centre for Neuroimaging and Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland., Kircher TTJ; Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany., Krug A; Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany., Lagerberg TV; NORMENT KG Jebsen Centre, University of Oslo, Oslo, Norway., Lenroot RK; School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.; Department of Psychiatry and Behavioural Sciences, University of New Mexico, Albuquerque, NM, USA., López-Jaramillo C; Research Group in Psychiatry, Department of Psychiatry, Faculty of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia.; Mood Disorders Program, Hospital Universitario San Vicente Fundación, Medellín, Antioquia, Colombia., Machado-Vieira R; Laboratory of Psychiatric Neuroimaging (LIM-21), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.; Department of Psychiatry, University of Texas Health Science Center at Houston, Houston, TX, USA., Malt UF; Psychosomatic Unit, Division of Mental Health and Dependence, Oslo University Hospital and University of Oslo, Oslo, Norway.; University of Oslo, Institute of Clinical Medicine, Oslo, Norway., McDonald C; Centre for Neuroimaging and Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland., Mitchell PB; School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.; Black Dog Institute, Prince of Wales Hospital, Sydney, NSW, Australia., Mwangi B; Department of Psychiatry, University of Texas Health Science Center at Houston, Houston, TX, USA., Nabulsi L; Centre for Neuroimaging and Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland., Opel N; Department of Psychiatry, University of Münster, Münster, Germany., Overs BJ; Neuroscience Research Australia, Sydney, NSW, Australia., Pineda-Zapata JA; Research Group, Instituto de Alta Tecnología Médica (IATM), Medellín, Antioquia, Colombia., Pomarol-Clotet E; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain., Redlich R; Department of Psychiatry, University of Münster, Münster, Germany., Roberts G; School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.; Black Dog Institute, Prince of Wales Hospital, Sydney, NSW, Australia., Rosa PG; Laboratory of Psychiatric Neuroimaging (LIM-21), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.; Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of São Paulo, São Paulo, Brazil., Salvador R; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain., Satterthwaite TD; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA., Soares JC; Department of Psychiatry, University of Texas Health Science Center at Houston, Houston, TX, USA., Stein DJ; Department of Psychiatry, SA MRC Unit on Risk & Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa., Temmingh HS; Department of Psychiatry, SA MRC Unit on Risk & Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa.; Western Cape Department of Health, Valkenberg Hospital, Cape Town, Western Cape, South Africa., Trappenberg T; Faculty of Computer Science, Dalhousie University, Halifax, Nova Scotia, Canada., Uhlmann A; Department of Psychiatry, SA MRC Unit on Risk & Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa.; Department of Psychiatry, University of Vermont, Burlington, VT, USA., van Haren NEM; Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Centre, Rotterdam, The Netherlands., Vieta E; Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain., Westlye LT; NORMENT KG Jebsen Centre, University of Oslo, Oslo, Norway.; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Department of Psychology, University of Oslo, Oslo, Norway., Wolf DH; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA., Yüksel D; Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany., Zanetti MV; Laboratory of Psychiatric Neuroimaging (LIM-21), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.; Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of São Paulo, São Paulo, Brazil.; Instituto de Ensino e Pesquisa, Hospital Sírio-Libanês, Sao Paulo, Brazil., Andreassen OA; NORMENT KG Jebsen Centre, University of Oslo, Oslo, Norway.; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Thompson PM; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA., Hajek T; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada. tomas.hajek@dal.ca.
Jazyk: angličtina
Zdroj: Molecular psychiatry [Mol Psychiatry] 2020 Sep; Vol. 25 (9), pp. 2130-2143. Date of Electronic Publication: 2018 Aug 31.
DOI: 10.1038/s41380-018-0228-9
Abstrakt: Bipolar disorders (BDs) are among the leading causes of morbidity and disability. Objective biological markers, such as those based on brain imaging, could aid in clinical management of BD. Machine learning (ML) brings neuroimaging analyses to individual subject level and may potentially allow for their diagnostic use. However, fair and optimal application of ML requires large, multi-site datasets. We applied ML (support vector machines) to MRI data (regional cortical thickness, surface area, subcortical volumes) from 853 BD and 2167 control participants from 13 cohorts in the ENIGMA consortium. We attempted to differentiate BD from control participants, investigated different data handling strategies and studied the neuroimaging/clinical features most important for classification. Individual site accuracies ranged from 45.23% to 81.07%. Aggregate subject-level analyses yielded the highest accuracy (65.23%, 95% CI = 63.47-67.00, ROC-AUC = 71.49%, 95% CI = 69.39-73.59), followed by leave-one-site-out cross-validation (accuracy = 58.67%, 95% CI = 56.70-60.63). Meta-analysis of individual site accuracies did not provide above chance results. There was substantial agreement between the regions that contributed to identification of BD participants in the best performing site and in the aggregate dataset (Cohen's Kappa = 0.83, 95% CI = 0.829-0.831). Treatment with anticonvulsants and age were associated with greater odds of correct classification. Although short of the 80% clinically relevant accuracy threshold, the results are promising and provide a fair and realistic estimate of classification performance, which can be achieved in a large, ecologically valid, multi-site sample of BD participants based on regional neurostructural measures. Furthermore, the significant classification in different samples was based on plausible and similar neuroanatomical features. Future multi-site studies should move towards sharing of raw/voxelwise neuroimaging data.
Databáze: MEDLINE