Statins everyday versus alternate days: Is there a difference in myalgia rates?

Autor:	Riaz R; Dow Medical College, Dow university of Health Sciences, Karachi, Pakistan., Merchant AZ; Dow Medical College, Dow university of Health Sciences, Karachi, Pakistan., Ul Haq MS; Dow Medical College, Dow university of Health Sciences, Karachi, Pakistan., Nasir SAR; Dow Medical College, Dow university of Health Sciences, Karachi, Pakistan., Rizvi Y; Dow Medical College, Dow university of Health Sciences, Karachi, Pakistan. Electronic address: yusrarizvi9910@gmail.com., Khan JA; Dow Medical College, Dow university of Health Sciences, Karachi, Pakistan., Zakaria SM; Dow Medical College, Dow university of Health Sciences, Karachi, Pakistan., Jawed H; Dow Medical College, Dow university of Health Sciences, Karachi, Pakistan., Hamid K; Dow Medical College, Dow university of Health Sciences, Karachi, Pakistan., Zehra NU; Dow Medical College, Dow university of Health Sciences, Karachi, Pakistan., Ahmed M; Dow Medical College, Dow university of Health Sciences, Karachi, Pakistan., Ali HA; Dow Medical College, Dow university of Health Sciences, Karachi, Pakistan., Fatima K; Dow Medical College, Dow university of Health Sciences, Karachi, Pakistan.
Jazyk:	angličtina
Zdroj:	Indian heart journal [Indian Heart J] 2018 Jul - Aug; Vol. 70 (4), pp. 492-496. Date of Electronic Publication: 2017 Nov 03.
DOI:	10.1016/j.ihj.2017.10.018
Abstrakt:	Objective: Statins are widely used drugs, known to cause myalgia, leading to high discontinuation rates. The objective of our study was to determine the frequency of myalgia in patients on everyday-dose (EDD) regimen with those on alternate-day dose (ADD) regimen. Methods: This cross sectional study was conducted in a tertiary care hospital of Pakistan. A sample size of 400 patients between the age of 40-70 years, taking simvastatin 40mg for at least 6 months or more were selected. Patients with prior musculoskeletal or neuromuscular complains, and family history of muscular disorders were excluded. Subjects were evaluated for myalgia via a self-administered questionnaire, and those complaining of myalgia were then evaluated for serum vitamin D levels. Data was analyzed through SPSS 16.0 and compared using chi square test. Results: The overall prevalence of myalgia was 7% (28/400). Frequency of myalgia in patients taking simvastatin everyday (n=20, 10%) was significantly higher compared to those taking it every alternate day (n=8, 4%) (p=0.02). There was no significant difference between the time of onset, nature, severity, type, or location of myalgia between the 2 groups. The most common cited triggering factor for pain was physical exercise. Of the patients experiencing myalgia, 13 (6.5%) from the EDD group and 6 (3%) from the ADD group had low levels of vitamin D. Conclusions: ADD regime was better tolerated by the patients than EDD regime. Alternate day therapy, with or without vitamin D supplementation, may be used by the physicians for troublesome muscular complains. (Copyright © 2017. Published by Elsevier B.V.)
Databáze:	MEDLINE
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