Moderate-intensity exercise and renin angiotensin system blockade improve the renovascular hypertension (2K1C)-induced gastric dysmotility in rats.

Autor: de Sousa Lima EB; Postgraduate Program in Pharmacology, Federal University of Piauí, Teresina, PI, Brazil., de Oliveira LCS; Postgraduate Program in Food and Nutrition, Federal University of Piauí, Teresina, PI, Brazil., da Silva Cardoso G; Department of Physical Education, Federal University of Piauí, Teresina, PI, Brazil., Telles PVN; Department of Physical Education, Federal University of Piauí, Teresina, PI, Brazil., da Costa Lima L; Department of Physical Education, Federal University of Piauí, Teresina, PI, Brazil., Reis E Sousa JF; Department of Physical Education, Federal University of Piauí, Teresina, PI, Brazil., Araújo RPN; Postgraduate Program in Pharmacology, Federal University of Piauí, Teresina, PI, Brazil., de Oliveira AP; Postgraduate Program in Pharmacology, Federal University of Piauí, Teresina, PI, Brazil., Dos Santos RF; Postgraduate Program in Pharmacology, Federal University of Piauí, Teresina, PI, Brazil., Dos Santos AA; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil., da Silva MTB; Postgraduate Program in Pharmacology, Federal University of Piauí, Teresina, PI, Brazil; Postgraduate Program in Food and Nutrition, Federal University of Piauí, Teresina, PI, Brazil; Department of Physical Education, Federal University of Piauí, Teresina, PI, Brazil. Electronic address: tolentino@ufpi.edu.br.
Jazyk: angličtina
Zdroj: Life sciences [Life Sci] 2018 Oct 01; Vol. 210, pp. 55-64. Date of Electronic Publication: 2018 Aug 28.
DOI: 10.1016/j.lfs.2018.08.053
Abstrakt: Actually, arterial hypertension is a major public health concern, which involves the renin angiotensin aldosterone system (RAS), via activation of the angiotensin receptors AT 1 and AT 2 of the cardiovascular system. Although angiotensin is an important stimulant of the gut permeability to sodium and water, little is known about the effects of arterial hypertension on gut motor behavior. Thus, we evaluated in rats the effect of hypertension induced by two-kidney one-clip (2K1C) model on the gastric motility, as well as the influence of exercise and RAS blockers treatment in such phenomenon. One week after surgery the rats were treated with Aliskiren (50 mg·kg -1 , p.o.), Captopril (50 mg·kg -1 , p.o.) or Losartan (10 mg·kg -1 , p.o). Other group of rats was submitted to swimming with 5% body weight overload. After 4 weeks of physical training or pharmacological treatment, we assessed the gastric retention in all groups (GR) of a liquid test meal, the mean arterial pressure (MAP), the heart rate (HR) and the HR variation (HRV) as well as the in vitro contractility of gastric fundus. Renovascular hypertension increased (p < 0.05) the GR, MAP and HR, a phenomenon prevented by pretreatment with RAS blockers or exercise. The two kidney one-clip Hypertension (2K1C) decreased (p < 0.05) the gastric fundus responsiveness, a phenomenon also prevented by exercise. It conclusion, renovascular hypertension delays the gastric emptying of liquids, a phenomenon involving the activation of RAS, where exercise or blockade with aliskiren, captopril and losartan prevent gastric dysmotility.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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