| Autor: |
Gnatenko DA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia. gnatenkodmitrij@gmail.com., Kopantzev EP; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia., Sverdlov ED; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia. |
| Jazyk: |
angličtina |
| Zdroj: |
Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2018 Jul; Vol. 481 (1), pp. 217-218. Date of Electronic Publication: 2018 Aug 31. |
| DOI: |
10.1134/S1607672918040105 |
| Abstrakt: |
Stimulation of BxPC-3, Panc-1, and MIA PaCA-2 pancreatic cancer cells with EGF, HGF, FGF-1, FGF-2, FGF-7, and FGF-10 growth factors caused changes in the expression of master genes regulating pancreatic development (SOX9, HNF3b, GATA-4, GATA-6, and HES1). This, in turn, caused changes in the expression profile of important transcription factors, embryonic development regulators. It was also found that the master genes belonging to the same family may cause opposite effects (suppression or enhancement of expression of a particular transcriptional regulator) in the same cell line. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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