Efficacy and safety of perampanel oral loading in postanoxic super-refractory status epilepticus: A pilot study.

Autor: Beretta S; Epilepsy Center, San Gerardo Hospital Monza, University of Milano Bicocca, Monza, Italy., Padovano G; Epilepsy Center, San Gerardo Hospital Monza, University of Milano Bicocca, Monza, Italy., Stabile A; Epilepsy Center, San Gerardo Hospital Monza, University of Milano Bicocca, Monza, Italy., Coppo A; Department of Intensive Care, San Gerardo Hospital Monza, Monza, Italy., Bogliun G; Epilepsy Center, San Gerardo Hospital Monza, University of Milano Bicocca, Monza, Italy., Avalli L; Department of Intensive Care, San Gerardo Hospital Monza, Monza, Italy., Ferrarese C; Epilepsy Center, San Gerardo Hospital Monza, University of Milano Bicocca, Monza, Italy.
Jazyk: angličtina
Zdroj: Epilepsia [Epilepsia] 2018 Oct; Vol. 59 Suppl 2, pp. 243-248. Date of Electronic Publication: 2018 Aug 29.
DOI: 10.1111/epi.14492
Abstrakt: Refractory nonconvulsive status epilepticus (NCSE) occurs in 10%-30% of patients following resuscitation after cardiac arrest. Both the optimal treatment and prognosis of postanoxic status epilepticus remain uncertain. We analyzed acute electroencephalographic changes, neurological outcome at 3 months, and adverse effects in consecutive postanoxic patients with super-refractory NCSE treated with add-on oral loading of perampanel. Eight postanoxic patients with super-refractory NCSE were treated with perampanel (dose range = 6-12 mg). All patients had continuous electroencephalographic monitoring showing definite generalized NCSE and favorable multimodal prognostic indicators (presence of brainstem reflexes, presence of bilateral N20 responses, absence of periodic discharges/generalized epileptic periodic discharges). In six patients (75%), status epilepticus resolved within 72 hours after administration of perampanel, without changing the comedication. Neurological outcomes at 3 months were return to normal or minimal disability in four patients (50%). A mild cholestatic liver injury, which required no specific treatment, was observed in five patients (62.5%). Perampanel 6-12 mg oral loading appeared to be an effective option in selected patients with postanoxic super-refractory NCSE with good prognostic indicators. In this patient population, our safety data indicate a risk of cholestasis.
(Wiley Periodicals, Inc. © 2018 International League Against Epilepsy.)
Databáze: MEDLINE
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