An antiviral factor from Melia azedarach L. prevents Tacaribe virus encephalitis in mice.

Autor: Andrei GM, Lampuri JS, Coto CE, de Torres RA
Jazyk: angličtina
Zdroj: Experientia [Experientia] 1986 Jul 15; Vol. 42 (7), pp. 843-5.
DOI: 10.1007/BF01941548
Abstrakt: Treatment of neonatal mice with an antiviral factor, (AVF), obtained from the leaves of Melia azedarach L. protected them against lethal encephalitis caused by Tacaribe virus inoculation. The degree of protection obtained varied from 66% to 100% depending on the virus dose. Similarly, administration of AVF to nursing mothers protected their offspring from developing virus encephalitis. AVF does not directly inactivate Tacaribe virus; it inhibits an early step (s) in the replication process in cell cultures.
Databáze: MEDLINE