Copper-Catalyzed Synthesis of Activated Sulfonate Esters from Boronic Acids, DABSO, and Pentafluorophenol.
| Autor: | Vedovato V; Department of Chemistry , University of Oxford, Chemistry Research Laboratory , Mansfield Road , Oxford OX1 3TA , United Kingdom., Talbot EPA; GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage SG1 2NY , United Kingdom., Willis MC; Department of Chemistry , University of Oxford, Chemistry Research Laboratory , Mansfield Road , Oxford OX1 3TA , United Kingdom. |
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| Jazyk: | angličtina |
| Zdroj: | Organic letters [Org Lett] 2018 Sep 07; Vol. 20 (17), pp. 5493-5496. Date of Electronic Publication: 2018 Aug 28. |
| DOI: | 10.1021/acs.orglett.8b02445 |
| Abstrakt: | The synthesis of pentafluorophenyl (PFP) sulfonate esters based on the Pd-catalyzed sulfination of aryl and heteroaryl boronic acids is reported. The sulfinate intermediates are converted in situ to the corresponding sulfonate esters using a copper-catalyzed oxidative process, providing a broad range of PFP esters in good yields. |
| Databáze: | MEDLINE |
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