The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses.

Autor: Goldstein T; One Health Institute & Karen C. Drayer Wildlife Health Center, School of Veterinary Medicine, University of California, Davis, CA, USA. tgoldstein@ucdavis.edu., Anthony SJ; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA. sja2127@cumc.columbia.edu.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA. sja2127@cumc.columbia.edu.; EcoHealth Alliance, New York, NY, USA. sja2127@cumc.columbia.edu., Gbakima A; Metabiota, Inc. Sierra Leone, Freetown, Sierra Leone., Bird BH; One Health Institute & Karen C. Drayer Wildlife Health Center, School of Veterinary Medicine, University of California, Davis, CA, USA., Bangura J; Metabiota, Inc. Sierra Leone, Freetown, Sierra Leone., Tremeau-Bravard A; One Health Institute & Karen C. Drayer Wildlife Health Center, School of Veterinary Medicine, University of California, Davis, CA, USA., Belaganahalli MN; One Health Institute & Karen C. Drayer Wildlife Health Center, School of Veterinary Medicine, University of California, Davis, CA, USA., Wells HL; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA., Dhanota JK; One Health Institute & Karen C. Drayer Wildlife Health Center, School of Veterinary Medicine, University of California, Davis, CA, USA., Liang E; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA.; EcoHealth Alliance, New York, NY, USA., Grodus M; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA., Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA., DeJesus VA; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA., Lasso G; Department of Systems Biology, Irving Cancer Research Center, Columbia University, New York, NY, USA., Smith BR; One Health Institute & Karen C. Drayer Wildlife Health Center, School of Veterinary Medicine, University of California, Davis, CA, USA., Jambai A; Ministry of Health and Sanitation, Freetown, Sierra Leone., Kamara BO; Ministry of Health and Sanitation, Makeni, Sierra Leone., Kamara S; Livestock and Veterinary Services Division, Ministry of Agriculture, Forestry and Food Security, Freetown, Sierra Leone., Bangura W; Forestry and Wildlife Division, Ministry of Agriculture, Forestry and Food Security, Freetown, Sierra Leone., Monagin C; One Health Institute & Karen C. Drayer Wildlife Health Center, School of Veterinary Medicine, University of California, Davis, CA, USA.; Metabiota, Inc., San Francisco, CA, USA., Shapira S; Department of Systems Biology, Irving Cancer Research Center, Columbia University, New York, NY, USA.; Department of Microbiology & Immunology, Columbia University, New York, NY, USA., Johnson CK; One Health Institute & Karen C. Drayer Wildlife Health Center, School of Veterinary Medicine, University of California, Davis, CA, USA., Saylors K; Metabiota, Inc., San Francisco, CA, USA., Rubin EM; Metabiota, Inc., San Francisco, CA, USA., Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA., Lipkin WI; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA., Mazet JAK; One Health Institute & Karen C. Drayer Wildlife Health Center, School of Veterinary Medicine, University of California, Davis, CA, USA.
Jazyk: angličtina
Zdroj: Nature microbiology [Nat Microbiol] 2018 Oct; Vol. 3 (10), pp. 1084-1089. Date of Electronic Publication: 2018 Aug 27.
DOI: 10.1038/s41564-018-0227-2
Abstrakt: Here we describe the complete genome of a new ebolavirus, Bombali virus (BOMV) detected in free-tailed bats in Sierra Leone (little free-tailed (Chaerephon pumilus) and Angolan free-tailed (Mops condylurus)). The bats were found roosting inside houses, indicating the potential for human transmission. We show that the viral glycoprotein can mediate entry into human cells. However, further studies are required to investigate whether exposure has actually occurred or if BOMV is pathogenic in humans.
Databáze: MEDLINE