Notch Signaling in the Tumor Microenvironment.

Autor:	Meurette O; Apoptosis, Cancer and Development Laboratory- Equipe Labellisée 'La Ligue', LabEx DEVweCAN, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon, Centre Léon Bérard, 69008 Lyon, France. Electronic address: olivier.meurette@lyon.unicancer.fr., Mehlen P; Apoptosis, Cancer and Development Laboratory- Equipe Labellisée 'La Ligue', LabEx DEVweCAN, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon, Centre Léon Bérard, 69008 Lyon, France.
Jazyk:	angličtina
Zdroj:	Cancer cell [Cancer Cell] 2018 Oct 08; Vol. 34 (4), pp. 536-548. Date of Electronic Publication: 2018 Aug 23.
DOI:	10.1016/j.ccell.2018.07.009
Abstrakt:	The Notch signaling pathway regulates many aspects of cancer biology. Most attention has been given to its role in the transformed cell. However, it is now clear that cancer progression and metastasis depend on the bidirectional interactions between cancer cells and their environment, forming the tumor microenvironment (TME). These interactions are mediated and constantly evolve through paracrine and juxtacrine signaling. In this review, we discuss how Notch signaling takes an important part in regulating the crosstalk between the different compartments of the TME. We also address the consequences of the Notch-TME involvement from a therapeutic perspective. (Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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