Memantine has no effect on K ATP channels in pancreatic β cells.

Autor: Imai R; Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan. imai-r@fmu.ac.jp.; Tsumura Kampo Research Laboratories, Kampo Research & Development Division, Tsumura & Co., Ibaraki, Japan. imai-r@fmu.ac.jp., Misaka S; Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan., Horita S; Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan., Yokota S; Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan., O'hashi R; Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan., Maejima Y; Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan., Shimomura K; Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan.
Jazyk: angličtina
Zdroj: BMC research notes [BMC Res Notes] 2018 Aug 25; Vol. 11 (1), pp. 614. Date of Electronic Publication: 2018 Aug 25.
DOI: 10.1186/s13104-018-3715-9
Abstrakt: Objective: Memantine, a drug for Alzheimer's disease, is considered to suppress excessive stimulation of N-methyl-D-aspartic acid receptors and to prevent neuronal death. However, a recent report indicated that the neuronal K ATP channel also can become a target of memantine. The K ATP channel is a key regulator of insulin secretion in pancreatic β cells. Therefore, if memantine could inhibit the K ATP channel in pancreatic β cells, it would be an effective drug for both Alzheimer's disease and diabetes. However, there is no report on the effect of memantine on the K ATP channel in pancreatic β cells. Therefore, we investigated whether memantine affect the blood glucose level, insulin secretion and K ATP channel activity in pancreatic β cells.
Results: An intraperitoneal glucose tolerance test was performed with or without memantine (1 mg/kg) injection in intact mice. Insulin secretion from isolated islets was measured under low (2 mM) and high (20 mM) glucose concentrations with or without memantine (1 μM). The effect of memantine (1 μM) on K ATP channel currents in isolated pancreatic β cells was recorded using the whole-cell patch-clamp technique. Memantine had no effect on the blood glucose level, insulin secretion from isolated islets or K ATP channel current in pancreatic β cells.
Databáze: MEDLINE
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