Islet microRNAs in health and type-2 diabetes.

Autor: Wendt A; Islet Cell Exocytosis, Lund University Diabetes Centre, Department of Clinical Sciences Malmö, Lund University and Clinical Research Centre, SUS, Malmö, Sweden., Esguerra JL; Islet Cell Exocytosis, Lund University Diabetes Centre, Department of Clinical Sciences Malmö, Lund University and Clinical Research Centre, SUS, Malmö, Sweden., Eliasson L; Islet Cell Exocytosis, Lund University Diabetes Centre, Department of Clinical Sciences Malmö, Lund University and Clinical Research Centre, SUS, Malmö, Sweden. Electronic address: lena.eliasson@med.lu.se.
Jazyk: angličtina
Zdroj: Current opinion in pharmacology [Curr Opin Pharmacol] 2018 Dec; Vol. 43, pp. 46-52. Date of Electronic Publication: 2018 Aug 23.
DOI: 10.1016/j.coph.2018.08.003
Abstrakt: Failure of the β-cell to secrete enough insulin is a major contributing factor in the pathogenesis of type-2 diabetes (T2D). MicroRNAs provide an extra layer in the regulation of protein expression, and are thus involved in β-cell compensation during development of the disease. In this review, we discuss how microRNAs can regulate their target protein expression and phenotypic output, present the status of nutritional regulation of microRNA expression, and summarize work on microRNA expression in human islets. In conclusion, current data lend support to microRNAs being essential regulators of insulin secretion. Future work will describe microRNAs in α-cell function, details of the microRNA-mRNA network, and possibilities to use microRNAs as biomarkers and in therapeutic treatment of T2D and complications.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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