Disconnection due to white matter hyperintensities is associated with lower cognitive scores.

Autor: Langen CD; Department of Radiology and Nuclear Medicine, Erasmus MC, PO Box 2040, 3000CA, Rotterdam, the Netherlands; Department of Medical Informatics, Erasmus MC, PO Box 2040, 3000CA, Rotterdam, the Netherlands. Electronic address: carolyn@almende.org., Cremers LGM; Department of Radiology and Nuclear Medicine, Erasmus MC, PO Box 2040, 3000CA, Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC, PO Box 2040, 3000CA, Rotterdam, the Netherlands. Electronic address: l.g.m.cremers@erasmusmc.nl., de Groot M; Department of Radiology and Nuclear Medicine, Erasmus MC, PO Box 2040, 3000CA, Rotterdam, the Netherlands; Department of Medical Informatics, Erasmus MC, PO Box 2040, 3000CA, Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC, PO Box 2040, 3000CA, Rotterdam, the Netherlands. Electronic address: marius.degroot@erasmusmc.nl., White T; Department of Radiology and Nuclear Medicine, Erasmus MC, PO Box 2040, 3000CA, Rotterdam, the Netherlands; Department of Child and Adolescent Psychiatry, Erasmus MC, PO Box 2040, 3000CA, Rotterdam, the Netherlands. Electronic address: t.white@erasmusmc.nl., Ikram MA; Department of Radiology and Nuclear Medicine, Erasmus MC, PO Box 2040, 3000CA, Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC, PO Box 2040, 3000CA, Rotterdam, the Netherlands. Electronic address: m.a.ikram@erasmusmc.nl., Niessen WJ; Department of Radiology and Nuclear Medicine, Erasmus MC, PO Box 2040, 3000CA, Rotterdam, the Netherlands; Department of Medical Informatics, Erasmus MC, PO Box 2040, 3000CA, Rotterdam, the Netherlands; Imaging Physics, Faculty of Applied Sciences, PO Box 5046, 2600GA, Delft University of Technology, Delft, the Netherlands. Electronic address: w.niessen@erasmusmc.nl., Vernooij MW; Department of Radiology and Nuclear Medicine, Erasmus MC, PO Box 2040, 3000CA, Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC, PO Box 2040, 3000CA, Rotterdam, the Netherlands. Electronic address: m.vernooij@erasmusmc.nl.
Jazyk: angličtina
Zdroj: NeuroImage [Neuroimage] 2018 Dec; Vol. 183, pp. 745-756. Date of Electronic Publication: 2018 Aug 23.
DOI: 10.1016/j.neuroimage.2018.08.037
Abstrakt: Previous studies have linked global burden of age-related white matter hyperintensities (WMHs) to cognitive impairment. We aimed to determine how WMHs in individual white matter connections relate to measures of cognitive function relative to measures of connectivity which do not take WMHs into account. Brain connectivity and WMH-related disconnectivity were derived from 3714 participants of the population-based Rotterdam Study. Connectivity was represented by the structural connectome, which was defined using diffusion tensor data, whereas the disconnectome represented disconnectivity due to WMH. The relationship between (dis)connectivity and cognitive measures was estimated using linear regression. We found that lower disconnectivity and higher connectivity corresponded to better cognitive function. There were many more significant associations with cognitive function in the disconnectome than in the connectome. Most connectome associations attenuated when disconnection was included in the model. WMH-related disconnectivity was especially related to worse executive functioning. Better cognitive speed corresponded to higher connectivity in specific connections independent of WMH presence. We conclude that WMH-related disconnectivity explains more variation in cognitive function than does connectivity. Efficient wiring in specific connections is important to information processing speed independent of WMH presence.
(Copyright © 2018. Published by Elsevier Inc.)
Databáze: MEDLINE
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