Psoriasis Plays a Wild CARD.
| Autor: | Van Nuffel E; Unit of Molecular Signal Transduction in Inflammation, Center for Inflammation Research, VIB, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Afonina IS; Unit of Molecular Signal Transduction in Inflammation, Center for Inflammation Research, VIB, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Beyaert R; Unit of Molecular Signal Transduction in Inflammation, Center for Inflammation Research, VIB, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium. Electronic address: Rudi.Beyaert@irc.vib-ugent.be. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | The Journal of investigative dermatology [J Invest Dermatol] 2018 Sep; Vol. 138 (9), pp. 1903-1905. |
| DOI: | 10.1016/j.jid.2018.05.001 |
| Abstrakt: | Rare autosomal mutations in CARD14 have previously been linked to psoriasis susceptibility in humans, but their pathogenic role had not been shown. Mellett et al. generated mice harboring the patient-derived gain-of-function Card14ΔE138 mutation and showed that hyperactivation of CARD14 alone is sufficient to induce immunopathogenic mechanisms that are responsible for psoriasis, which is driven by the IL-17/IL-23 axis. (Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|