Serial Endoscopic Evaluation of Esophageal Disease in a Cancer Model: A Paradigm Shift for Esophageal Adenocarcinoma (EAC) Drug Discovery and Development.

Autor: Omstead AN; a Esophageal and Lung Institute , Allegheny Health Network , Pittsburgh , PA , USA., Kosovec JE; a Esophageal and Lung Institute , Allegheny Health Network , Pittsburgh , PA , USA., Matsui D; b Department of Gastroenterological Surgery , Kanazawa University Hospital , Kanazawa , Ishikawa , Japan., Martin SA; a Esophageal and Lung Institute , Allegheny Health Network , Pittsburgh , PA , USA., Smith MA; c Department of Pathology and Laboratory Medicine , Allegheny Health Network , Pittsburgh , PA , USA., Aaron Guel D; a Esophageal and Lung Institute , Allegheny Health Network , Pittsburgh , PA , USA., Kolano J; a Esophageal and Lung Institute , Allegheny Health Network , Pittsburgh , PA , USA., Komatsu Y; a Esophageal and Lung Institute , Allegheny Health Network , Pittsburgh , PA , USA., Habib F; a Esophageal and Lung Institute , Allegheny Health Network , Pittsburgh , PA , USA., Lai C; a Esophageal and Lung Institute , Allegheny Health Network , Pittsburgh , PA , USA., Christopher K; a Esophageal and Lung Institute , Allegheny Health Network , Pittsburgh , PA , USA., Kelly RJ; d Department of Oncology, Sidney Kimmel Comprehensive Cancer Center , Johns Hopkins Hospital , Baltimore , MD , USA., Zaidi AH; a Esophageal and Lung Institute , Allegheny Health Network , Pittsburgh , PA , USA., Jobe BA; a Esophageal and Lung Institute , Allegheny Health Network , Pittsburgh , PA , USA.
Jazyk: angličtina
Zdroj: Cancer investigation [Cancer Invest] 2018; Vol. 36 (7), pp. 363-370. Date of Electronic Publication: 2018 Aug 24.
DOI: 10.1080/07357907.2018.1499029
Abstrakt: A rat model of surgically induced reflux recapitulates the development and progression of human esophageal adenocarcinoma (EAC). In this study, reflux was induced in rats followed by postoperative endoscopy with biopsy, to diagnose and monitor disease progression. Overall, percentage agreement between visual endoscopy and gold standard histology was 95%, with disease-specific classification accuracies of 100% and 75% for Barrett's with dysplasia and EAC, respectively. Additionally, the percentage agreement for biopsy in tumors >4 mm was 75%. Thereby, establishing endoscopic evaluation as a reliable tool to assess disease progression and provide biopsies for downstream correlates in a de novo EAC model.
Databáze: MEDLINE
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