The role of neutrophils in cancer.
| Autor: | Grecian R; Medical Research Council Centre for Inflammation Research, The Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh, UK., Whyte MKB; Medical Research Council Centre for Inflammation Research, The Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh, UK., Walmsley SR; Medical Research Council Centre for Inflammation Research, The Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh, UK. |
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| Jazyk: | angličtina |
| Zdroj: | British medical bulletin [Br Med Bull] 2018 Dec 01; Vol. 128 (1), pp. 5-14. |
| DOI: | 10.1093/bmb/ldy029 |
| Abstrakt: | Introduction: It has been known for some time that neutrophils are present in the tumour microenvironment, but only recently have their roles been explored. Sources of Data: Comprehensive literature search of neutrophils and cancer (PubMed, Google Scholar and CrossRef) for key articles (systematic reviews, meta-analyses, primary research). References from these articles cross-checked for additional relevant studies. Areas of Agreement: Neutrophils are a heterogeneous population with both pro- and antitumour roles, and display plasticity. Several neutrophil subpopulations have been identified, defined by a combination of features (density, maturity, surface markers, morphology and anatomical site). Areas of Controversy: Limitations in translating murine tumour models to human pathology and paucity of human data. Consensus in defining human neutrophil subpopulations. Growing Points: Neutrophils as therapeutic targets and as possible playmakers in the biological response to newer targeted cancer drugs. Areas Timely for Developing Research: Understanding the metabolic programming of neutrophils in the tumour microenvironment. |
| Databáze: | MEDLINE |
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