Association of vitamin D receptor gene FokI polymorphism and susceptibility to CAP in Egyptian children: a multicenter study.

Autor: Abouzeid H; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt. abozeid_heba@yahoo.com., Abdelaal NM; Department of Pediatrics, Faculty of Medicine, Ain-Shams University, Cairo, Egypt., Abdou MA; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Mosabah AAA; Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt., Zakaria MT; Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt., Soliman MM; Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt., Sherif AM; Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt., Hamed ME; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Soliman AA; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Noah MA; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Khalil AM; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Hegab MS; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Abdel-Aziz A; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Elashkar SSA; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Nabil RM; Department of Clinical pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Abdou AM; Department of Clinical pathology, Al Azhar Faculty of Medicine, Cairo, Egypt., Al-Akad GM; Department of Clinical pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Elbasyouni HAA; Department of Internal Medicine, Faculty of Medicine, Menoufia University, Monufia, Egypt.
Jazyk: angličtina
Zdroj: Pediatric research [Pediatr Res] 2018 Nov; Vol. 84 (5), pp. 639-644. Date of Electronic Publication: 2018 Aug 15.
DOI: 10.1038/s41390-018-0149-y
Abstrakt: Background: Community-acquired pneumonia (CAP) is the leading cause of child deaths around the world. Recently, the vitamin D receptor (VDR) gene has emerged as a susceptibility gene for CAP.
Objectives: To evaluate the association of the VDR gene Fok I polymorphism with susceptibility to CAP in Egyptian children.
Methods: This was a multicenter case-control study of 300 patients diagnosed with CAP, and 300 well-matched healthy control children. The VDR Fok I (rs2228570) polymorphism was genotyped by PCR-restriction fragment length polymorphism (RFLP), meanwhile serum 25-hydroxy vitamin D (25D) level was assessed using ELISA method.
Results: The frequencies of the VDR FF genotype and F allele were more common in patients with CAP than in our control group (OR = 3.6; (95% CI: 1.9-6.7) for the FF genotype; P = 0.001) and (OR: 1.8; (95% CI: 1.4-2.3) for the F allele; P = 0.01). Patients carrying the VDR FF genotype had lower serum (25D) level (mean; 14.8 ± 3.6 ng/ml) than Ff genotype (20.6 ± 4.5 ng/ml) and the ff genotype (24.5 ± 3.7 ng/ml); P < 0.01.
Conclusion: The VDR gene Fok I (rs2228570) polymorphism confers susceptibility to CAP in Egyptian children.
Databáze: MEDLINE
Externí odkaz: