Phytol: A review of biomedical activities.

Autor: Islam MT; Department for Management of Science and Technology Development & Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, 700000, Viet Nam; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, 700000, Viet Nam. Electronic address: muhammad.torequl.islam@tdt.edu.vn., Ali ES; Flinders University College of Medicine and Public Health, Bedford Park, 5042, Adelaide, Australia., Uddin SJ; Pharmacy Discipline, Life Science School, Khulna University, Khulna, 9208, Bangladesh., Shaw S; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA., Islam MA; Pharmacy Discipline, Life Science School, Khulna University, Khulna, 9208, Bangladesh., Ahmed MI; Pharmacy Discipline, Life Science School, Khulna University, Khulna, 9208, Bangladesh., Chandra Shill M; Department of Pharmaceutical Sciences, North South University, Bashundhara, Dhaka, 1229, Bangladesh., Karmakar UK; Pharmacy Discipline, Life Science School, Khulna University, Khulna, 9208, Bangladesh., Yarla NS; Department of Animal Biology, School of Life Sciences, University of Hyderabad, Hyderabad, 500003, T.N., India., Khan IN; PK-NeuroOncology Research Group, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, 25000, Pakistan., Billah MM; Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna, 9208, Bangladesh., Pieczynska MD; Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, Jastrzebiec, Poland., Zengin G; Department of Biology, Science Faculty, Selcuk University, Konya, Turkey., Malainer C; Independent Researcher, Vienna, Austria., Nicoletti F; Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy., Gulei D; MEDFUTURE - Research Center for Advanced Medicine, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 23 Marinescu Street, 400337, Romania., Berindan-Neagoe I; MEDFUTURE - Research Center for Advanced Medicine, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 23 Marinescu Street, 400337, Romania; Research Center for Functional Genomics, Biomedicine and Translational Medicine, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 23 Marinescu Street, 400337, Cluj-Napoca, Romania; Department of Functional Genomics and Experimental Pathology, The Oncology Institute 'Prof. Dr. Ion Chiricuta', Republicii 34 Street, 400015, Cluj-Napoca, Romania., Apostolov A; Agricultural Institute, BG - 9700, Shumen, Bulgaria., Banach M; Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Poland; Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland; Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora, Poland., Yeung AWK; Oral and Maxillofacial Radiology, Applied Oral Sciences, Faculty of Dentistry, University of Hong Kong, Hong Kong, China., El-Demerdash A; Muséum national d'Histoire naturelle, Molécules de Communication et Adaptation des Micro-organismes, UMR 7245 CNRS/MNHN, Paris, France; Chemistry Department, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt., Xiao J; Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Avenida da Universidade, Taipa, Macau., Dey P; School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea., Yele S; School of Pharmacy and Technology Management, SVKM's NMIMS, Shirpur, India., Jóźwik A; Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, Jastrzebiec, Poland., Strzałkowska N; Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, Jastrzebiec, Poland., Marchewka J; Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, Jastrzebiec, Poland., Rengasamy KRR; REEF Environmental Consultancy Services, #2 Kamaraj Street, S.P. Nagar, Puducherry, 605 001, India., Horbańczuk J; Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, Jastrzebiec, Poland., Kamal MA; King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; Enzymoics, 7 Peterlee Place, Hebersham, NSW, 2770, Australia; Novel Global Community Educational Foundation, Australia., Mubarak MS; Department of Chemistry, The University of Jordan, Amman, 11942, Jordan., Mishra SK; Department of Zoology, School of Biological Sciences, Dr. Harisingh Gour Central University, Sagar, 470003, M.P., India., Shilpi JA; Pharmacy Discipline, Life Science School, Khulna University, Khulna, 9208, Bangladesh., Atanasov AG; Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, Jastrzebiec, Poland; Department of Pharmacognosy, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, A-1090, Vienna, Austria. Electronic address: atanas.atanasov@univie.ac.at.
Jazyk: angličtina
Zdroj: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2018 Nov; Vol. 121, pp. 82-94. Date of Electronic Publication: 2018 Aug 18.
DOI: 10.1016/j.fct.2018.08.032
Abstrakt: Phytol (PYT) is a diterpene member of the long-chain unsaturated acyclic alcohols. PYT and some of its derivatives, including phytanic acid (PA), exert a wide range of biological effects. PYT is a valuable essential oil (EO) used as a fragrance and a potential candidate for a broad range of applications in the pharmaceutical and biotechnological industry. There is ample evidence that PA may play a crucial role in the development of pathophysiological states. Focusing on PYT and some of its most relevant derivatives, here we present a systematic review of reported biological activities, along with their underlying mechanism of action. Recent investigations with PYT demonstrated anxiolytic, metabolism-modulating, cytotoxic, antioxidant, autophagy- and apoptosis-inducing, antinociceptive, anti-inflammatory, immune-modulating, and antimicrobial effects. PPARs- and NF-κB-mediated activities are also discussed as mechanisms responsible for some of the bioactivities of PYT. The overall goal of this review is to discuss recent findings pertaining to PYT biological activities and its possible applications.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: