Molecular Diagnostics for Mycobacterium tuberculosis Infection.

Autor:	Dicks KV; Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA; email: kristen.dicks@duke.edu , jason.stout@dm.duke.edu., Stout JE; Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA; email: kristen.dicks@duke.edu , jason.stout@dm.duke.edu.
Jazyk:	angličtina
Zdroj:	Annual review of medicine [Annu Rev Med] 2019 Jan 27; Vol. 70, pp. 77-90. Date of Electronic Publication: 2018 Aug 20.
DOI:	10.1146/annurev-med-040717-051502
Abstrakt:	Resistance to antimycobacterial drugs is a major barrier to effective treatment of Mycobacterium tuberculosis infection. Molecular diagnostic techniques based on the association between specific gene mutations and phenotypic resistance to certain drugs offer the opportunity to rapidly ascertain whether drug resistance is present and to alter treatment before further resistance develops. Current barriers to successful implementation of rapid diagnostics include imperfect knowledge regarding the full spectrum of mutations associated with resistance, limited utilization of molecular diagnostics where they are most needed, and the requirement for specialized laboratory facilities to perform molecular testing. Further understanding of genotypic-phenotypic correlates of resistance and streamlined implementation platforms will be necessary to optimize the public health impact of molecular resistance testing for M. tuberculosis.
Databáze:	MEDLINE
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