Cobalt Octacarbonyl-Catalyzed Scalable Alkyne Cyclotrimerization and Crossed [2 + 2 + 2]-Cycloaddition Reaction in a Plug Flow Reactor.

Autor:	García-Lacuna J; Facultad de Farmacia, Dpto. Química y Bioquímica , Universidad San Pablo CEU , Urb. Montepríncipe, Boadilla del Monte , 28668 Madrid , Spain., Domínguez G; Facultad de Farmacia, Dpto. Química y Bioquímica , Universidad San Pablo CEU , Urb. Montepríncipe, Boadilla del Monte , 28668 Madrid , Spain., Blanco-Urgoiti J; CSFlowChem SL , C/Boadilla del Camino 3 , 28050 Madrid , Spain., Pérez-Castells J; Facultad de Farmacia, Dpto. Química y Bioquímica , Universidad San Pablo CEU , Urb. Montepríncipe, Boadilla del Monte , 28668 Madrid , Spain.
Jazyk:	angličtina
Zdroj:	Organic letters [Org Lett] 2018 Sep 07; Vol. 20 (17), pp. 5219-5223. Date of Electronic Publication: 2018 Aug 20.
DOI:	10.1021/acs.orglett.8b02168
Abstrakt:	Cobalt-catalyzed alkyne cyclotrimerization and crossed [2 + 2 + 2] cycloadditions are developed in a plug flow reactor. The protocol generally uses 5 mol % of Co 2 (CO) 8 and is scalable at least at multigram scale. Efficient and scalable use of Co 2 (CO) 8 for crossed reactions of diynes and alkynes has hardly any precedent.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu