| Autor: |
Muñoz-Pérez MJ; Medicine School, Anáhuac University., Casco S; National Rehabilitation Institute, Mexico City, Mexico., Garza-González MDC; Oncological research center UNE-UPAEP, Puebla., Soto-Vega E; Medicine School, Anáhuac University. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2018 Nov; Vol. 40 (8), pp. e490-e494. |
| DOI: |
10.1097/MPH.0000000000001278 |
| Abstrakt: |
Acute lymphoblastic leukemia is the most important childhood cancer. Multidrug resistance is an important factor of poor prognosis. We present the P-glycoprotein (P-gp) activity in 2 patients with different outcomes. Both patients had B-cell acute lymphoblastic leukemia; they were responding properly to the treatment, but one of them had an increment in the P-gp activity that correlates with an increment in the disease manifestation, the patient had to be hospitalized and developed sepsis and subsequently died. P-gp levels were correlated with disease progression. P-gp activity needs to be evaluated during treatment to assess and prevent disease relapse or the patient´s death. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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