Expression of Mucins and Claudins in the Colon during Acute and Chronic Experimental Colitis.

Autor: Zolotova NA; Research Institute of Human Morphology, Moscow, Russia. natashazltv@gmail.com., Polikarpova AV; Research Institute of Human Morphology, Moscow, Russia., Khochanskii DN; Research Institute of Human Morphology, Moscow, Russia., Makarova OV; Research Institute of Human Morphology, Moscow, Russia., Mikhailova LP; Research Institute of Human Morphology, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2018 Aug; Vol. 165 (4), pp. 434-437. Date of Electronic Publication: 2018 Aug 20.
DOI: 10.1007/s10517-018-4187-6
Abstrakt: We studied changes in the expression of mRNA for mucins and claudins in the medial part of the colon in male C57Bl/6 mice on the model of acute and chronic colitis induced by substitution of drinking water with 1% solution of dextran sodium sulphate for 5 days. In acute colitis, the expression of the main structural component of glycocalyx, mucin Muc3, decreased and expression of pore-forming claudin Cldn2 increased, which reflected enhanced permeability of tight junctions. In the chronic colitis group, in comparison with the normal group, we observed an increase in expression of mRNA of main structural mucus component Muc2, enhanced of expression of Muc1 associated with carcinogenesis, and reduced expression of Muc13, which led to a more severe course of colitis; the expression of pore-forming claudin Cldn2 was elevated. These findings indicate that the imbalance in the expression of mucins and claudins plays an important role in the mechanisms of development of acute and chronic colitis.
Databáze: MEDLINE
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