The Claustrum Supports Resilience to Distraction.

Autor: Atlan G; Edmond and Lily Safra Center for Brain Sciences, Jerusalem, Israel., Terem A; Institute of Life Sciences, Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 91904, Israel., Peretz-Rivlin N; Edmond and Lily Safra Center for Brain Sciences, Jerusalem, Israel., Sehrawat K; Edmond and Lily Safra Center for Brain Sciences, Jerusalem, Israel., Gonzales BJ; Institute of Life Sciences, Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 91904, Israel., Pozner G; Institute of Life Sciences, Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 91904, Israel., Tasaka GI; Edmond and Lily Safra Center for Brain Sciences, Jerusalem, Israel., Goll Y; Institute of Life Sciences, Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 91904, Israel., Refaeli R; Edmond and Lily Safra Center for Brain Sciences, Jerusalem, Israel., Zviran O; Institute of Life Sciences, Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 91904, Israel., Lim BK; Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA., Groysman M; Edmond and Lily Safra Center for Brain Sciences, Jerusalem, Israel., Goshen I; Edmond and Lily Safra Center for Brain Sciences, Jerusalem, Israel., Mizrahi A; Edmond and Lily Safra Center for Brain Sciences, Jerusalem, Israel; Institute of Life Sciences, Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 91904, Israel., Nelken I; Edmond and Lily Safra Center for Brain Sciences, Jerusalem, Israel; Institute of Life Sciences, Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 91904, Israel., Citri A; Edmond and Lily Safra Center for Brain Sciences, Jerusalem, Israel; Institute of Life Sciences, Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 91904, Israel; Program in Child and Brain Development, Canadian Institute for Advanced Research, MaRS Centre, West Tower, 661 University Avenue, Suite 505, Toronto, ON M5G 1M1, Canada. Electronic address: ami.citri@mail.huji.ac.il.
Jazyk: angličtina
Zdroj: Current biology : CB [Curr Biol] 2018 Sep 10; Vol. 28 (17), pp. 2752-2762.e7. Date of Electronic Publication: 2018 Aug 16.
DOI: 10.1016/j.cub.2018.06.068
Abstrakt: A barrage of information constantly assaults our senses, of which only a fraction is relevant at any given point in time. However, the neural circuitry supporting the suppression of irrelevant sensory distractors is not completely understood. The claustrum, a circuit hub with vast cortical connectivity, is an intriguing brain structure, whose restrictive anatomy, thin and elongated, has precluded functional investigation. Here, we describe the use of Egr2-CRE mice to access genetically defined claustral neurons. Utilizing conditional viruses for anterograde axonal labeling and retrograde trans-synaptic tracing, we validated this transgenic model for accessing the claustrum and extended the known repertoire of claustral input/output connectivity. Addressing the function of the claustrum, we inactivated CL Egr2+ neurons, chronically as well as acutely, in mice performing an automated two-alternative forced-choice behavioral task. Strikingly, inhibition of CL Egr2+ neurons did not significantly impact task performance under varying delay times and cue durations, but revealed a selective role for the claustrum in supporting performance in the presence of an irrelevant auditory distractor. Further investigation of behavior, in the naturalistic maternal pup-retrieval task, replicated the result of sensitization to an auditory distractor following inhibition of CL Egr2+ neurons. Initiating investigation into the underlying mechanism, we found that activation of CL Egr2+ neurons modulated cortical sensory processing, suppressing tone representation in the auditory cortex. This functional study, utilizing selective genetic access, implicates the claustrum in supporting resilience to distraction, a fundamental aspect of attention.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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