Chikungunya in solid organ transplant recipients, a case series and literature review.

Autor: Rosso F; Infectious Diseases Service, Fundación Valle del Lili, Cali, Colombia.; Clinical Research Center, Fundación Valle del Lili, Cali, Colombia.; Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia., Rodríguez S; Clinical Research Center, Fundación Valle del Lili, Cali, Colombia., Cedano JA; Clinical Research Center, Fundación Valle del Lili, Cali, Colombia., Mora BL; Clinical Research Center, Fundación Valle del Lili, Cali, Colombia., Moncada PA; Infectious Diseases Service, Fundación Valle del Lili, Cali, Colombia., Velez JD; Infectious Diseases Service, Fundación Valle del Lili, Cali, Colombia.
Jazyk: angličtina
Zdroj: Transplant infectious disease : an official journal of the Transplantation Society [Transpl Infect Dis] 2018 Dec; Vol. 20 (6), pp. e12978. Date of Electronic Publication: 2018 Sep 03.
DOI: 10.1111/tid.12978
Abstrakt: Chikungunya virus is a recent emerging arbovirus in Latin America, and the clinical manifestations can vary from fever and rash to severe chronic inflammatory arthritis. Few reports have been published regarding this infection in immunocompromised patients, including solid organ transplant recipients. We report a case series of solid organ transplant recipients with confirmed Chikungunya infection by positive reverse transcription polymerase chain reaction (RT-PCR), identified between January 2014 and December 2016. In addition, we conducted a literature review searching PubMed, EMBASE, and LILACS databases on Chikungunya infection in solid organ transplant recipients. Ten solid organ transplant recipients were included, consisting of 5 kidney, 4 liver, and 1 liver/kidney transplant recipient. Mean age of the transplant recipients was 47 years, and the most frequent symptoms of Chikungunya infection were arthralgia and fever. None of the patients required treatment in the intensive care unit, no deaths or graft rejection occurred. None of our patients had recurrent arthritis during 3-month follow-up period after the infection. Twenty-one cases of Chikungunya virus were identified in the literature review. Most cases had a benign clinical course with no severe complications, death, or chronic inflammatory arthritis. In conclusion, Chikungunya infection in solid organ transplant recipients has a benign course and has no chronic recurrent arthritis. It is possible that the immunosuppression regimen could decrease the risk of severe or chronic inflammatory manifestations in solid organ transplant recipients infected with Chikungunya.
(© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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