| Autor: |
Olcay A; Department of Cardiology, İstanbul Aydin University Medical School, Beşyol Mahallesi, İnönü Cd. No:38, 34295, Küçükçekmece, İstanbul, Turkey. drayhanolcay@gmail.com., Tezcan E; Department of Nutrition and Dietetics, İstanbul Gedik University, İstanbul, Turkey., Canturk E; Department of Cardiovascular Surgery, Bezmialem Vakif University, İstanbul, Turkey., İnan B; Department of Cardiovascular Surgery, Bezmialem Vakif University, İstanbul, Turkey., Karaoglu H; İstanbul Institute of Forensic Medicine, İstanbul, Turkey., Kucuk C; İstanbul Institute of Forensic Medicine, İstanbul, Turkey., Akdemir B; Department of Cardiology, İstanbul Aydin University Medical School, Beşyol Mahallesi, İnönü Cd. No:38, 34295, Küçükçekmece, İstanbul, Turkey., Yolay O; Faculty of Health Sciences, Department of Nutrition and Dietetics, İstanbul Aydin University, İstanbul, Turkey. |
| Jazyk: |
angličtina |
| Zdroj: |
Biological trace element research [Biol Trace Elem Res] 2019 Jun; Vol. 189 (2), pp. 420-425. Date of Electronic Publication: 2018 Aug 17. |
| DOI: |
10.1007/s12011-018-1481-0 |
| Abstrakt: |
Population studies revealed that metal exposure through food, environment, and smoking was related with increased risk of cardiovascular disease. In this study, we determined complex chemical elements in surgical carotid endarterectomy specimens and carotid tissues from autopsies without atherosclerosis. Atherosclerotic plaques from 41 endarterectomies and normal carotid tissue from 30 autopsies were collected and elemental composition was determined by inductively coupled plasma optical emission spectrometry (ICP-OES) method. Eleven (26.8%) patients never smoked in carotid endarterectomy group. One patient was brass souvenir worker and one was goldsmith and others did not have direct contact with metals in the carotid endarterectomy group. Na, Cu, Mn, Bi, Co, Mo, Ni, Pb, Sb, Se, Sn, Ti, and W levels were not different between two groups. Bi, Co, Mo, Pb, Ti, and W were below the detection limit of ICP-OES in both groups. Concentrations of Mg, K, Ca, P, Fe, B, Zn, Al, As, Cr, Pt, and Hg were significantly higher in carotid endarterectomies than normal carotid tissue samples. Cd and S values were significantly higher in autopsy samples. There is significant multiple non-essential transition metal accumulation in atherosclerotic carotid endarterectomy plaques. The cardiovascular consequences of metal toxicity have not been researched adequately due to large emphasis on the role of cholesterol in atherosclerosis. High level of non-essential transition metal elements in the carotid atherosclerotic plaques may add the missing link of atherogenesis and may necessitate new treatment and prevention strategies in carotid disease if confirmed by further research. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Full text from SpringerLink