Fully coupled fluid-electro-mechanical model of the human heart for supercomputers.

Autor: Santiago A; Department of Computer Applications in Science and Engineering, Barcelona Supercomputing Center (BSC), Barcelona, Spain., Aguado-Sierra J; Department of Computer Applications in Science and Engineering, Barcelona Supercomputing Center (BSC), Barcelona, Spain., Zavala-Aké M; Department of Computer Applications in Science and Engineering, Barcelona Supercomputing Center (BSC), Barcelona, Spain., Doste-Beltran R; Physense, Universitat Pompeu Fabra, Barcelona, Spain., Gómez S; Department of Computer Applications in Science and Engineering, Barcelona Supercomputing Center (BSC), Barcelona, Spain., Arís R; Department of Computer Applications in Science and Engineering, Barcelona Supercomputing Center (BSC), Barcelona, Spain., Cajas JC; Department of Computer Applications in Science and Engineering, Barcelona Supercomputing Center (BSC), Barcelona, Spain., Casoni E; Department of Computer Applications in Science and Engineering, Barcelona Supercomputing Center (BSC), Barcelona, Spain., Vázquez M; Department of Computer Applications in Science and Engineering, Barcelona Supercomputing Center (BSC), Barcelona, Spain.; Instituto de Investigación en Inteligencia Artificial (IIIA), Consejo Superior de Investigaciones Científicas (CSIC), Barcelona, Spain.
Jazyk: angličtina
Zdroj: International journal for numerical methods in biomedical engineering [Int J Numer Method Biomed Eng] 2018 Dec; Vol. 34 (12), pp. e3140.
DOI: 10.1002/cnm.3140
Abstrakt: In this work, we present a fully coupled fluid-electro-mechanical model of a 50th percentile human heart. The model is implemented on Alya, the BSC multi-physics parallel code, capable of running efficiently in supercomputers. Blood in the cardiac cavities is modeled by the incompressible Navier-Stokes equations and an arbitrary Lagrangian-Eulerian (ALE) scheme. Electrophysiology is modeled with a monodomain scheme and the O'Hara-Rudy cell model. Solid mechanics is modeled with a total Lagrangian formulation for discrete strains using the Holzapfel-Ogden cardiac tissue material model. The three problems are simultaneously and bidirectionally coupled through an electromechanical feedback and a fluid-structure interaction scheme. In this paper, we present the scheme in detail and propose it as a computational cardiac workbench.
(© 2018 John Wiley & Sons, Ltd.)
Databáze: MEDLINE
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