| Autor: |
Bushnell CD; 1 Wake Forest School of Medicine, Winston Salem, NC, USA., Chaturvedi S; 2 Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA., Gage KR; 3 Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA., Herson PS; 4 Department of Anesthesiology, University of Colorado, Denver, CO, USA., Hurn PD; 5 School of Nursing, University of Michigan, Ann Arbor, MI, USA., Jiménez MC; 6 Division of Women's Health, Brigham and Women's Hospital, Boston, MA, USA., Kittner SJ; 7 Baltimore Veterans Administration Medical Center and Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA., Madsen TE; 8 Department of Emergency Medicine, Alpert Medical School of Brown University, Providence, RI, USA., McCullough LD; 9 Department of Neurology, University of Texas at Houston, Houston, TX, USA., McDermott M; 10 Stroke Program, University of Michigan, Ann Arbor, MI, USA., Reeves MJ; 11 Department of Epidemiology and Biostatistics, Michigan State University, Lansing, MI, USA., Rundek T; 2 Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA. |
| Abstrakt: |
Biologic sex influences many variables that are important to brain health in general, and to stroke or cerebral ischemia in particular, such as general health status, cerebrovascular anatomy and function, unique risk factors such as pregnancy and preeclampsia, symptomatology, and therapeutic response. A more complete understanding of the scale and depth of sexual dimorphism in the brain and the role of more general sex-based factors is crucial to reducing the burden of stroke in women and men. This focused review highlights recent findings in stroke, including sex differences in epidemiology, risk factor reduction, comparative use of stroke therapeutics in both sexes, the importance of frailty in women, and the biologic basis for sex differences in stroke. Such findings show tremendous promise for the future of personalized medicine in stroke prevention and treatment. |
