Prostate cancer risk factors in black and white men in the NIH-AARP Diet and Health Study.
Autor: | Layne TM; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. tracy.layne@nih.gov., Graubard BI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Ma X; Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.; Yale Comprehensive Cancer Center, Yale University, New Haven, CT, USA., Mayne ST; Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.; Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD, USA., Albanes D; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. |
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Jazyk: | angličtina |
Zdroj: | Prostate cancer and prostatic diseases [Prostate Cancer Prostatic Dis] 2019 Mar; Vol. 22 (1), pp. 91-100. Date of Electronic Publication: 2018 Aug 14. |
DOI: | 10.1038/s41391-018-0070-9 |
Abstrakt: | Background: There are few prospective studies comparing race-specific associations between diet, nutrients, and health-related parameters, and prostate cancer risk. Methods: Race-specific prostate cancer risk associations were examined among men in the National Institutes of Health (NIH)-AARP Diet and Health Study. We identified 1417 cases among black men (209 advanced), and 28,845 among white men (3898 advanced). Cox proportional hazards regression models estimated hazard ratios (HRs) and 95% confidence intervals (CIs). We also evaluated the cumulative change in the HR for black race following adjustment for each factor. Results: Race-specific prostate cancer associations were similar in black and white men across disease subtypes only for history of diabetes (overall : HR = 0.77, 95% CI: 0.65-0.90 and HR = 0.72, 95% CI: 0.69-0.76, respectively; P Conclusions: Our data suggest few of the dietary, nutrient, and health-related factors associated with prostate cancer risk in predominantly non-Hispanic white men were associated with risk in black men, and adjustment for these factors widen the black-white difference in risk. Larger studies of black men, particularly with prospective data, are needed to help identify risk factors relevant to this population. |
Databáze: | MEDLINE |
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