NO x in exhaled breath condensate is related to allergic sensitization in young and middle-aged adults.

Autor: Aldakheel FM; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia., Bourke JE; Department of Pharmacology, Biomedicine Discovery Institute, Monash University, Melbourne, Vic., Australia., Thomas PS; Department of Respiratory Medicine & Prince of Wales Hospital Clinical School, University of New South Wales, Kensington, NSW, Australia., Matheson MC; Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Vic., Australia.; Murdoch Children's Research Institute, Melbourne, Vic., Australia., Abramson MJ; School of Public Health & Preventive Medicine, Monash University, Melbourne, Vic., Australia., Hamilton GS; School of Clinical Sciences, Monash University, Melbourne, Vic., Australia.; Monash Lung and Sleep, Monash Health, Melbourne, Vic., Australia., Lodge CJ; Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Vic., Australia.; Murdoch Children's Research Institute, Melbourne, Vic., Australia., Thompson BR; Allergy, Immunology and Respiratory Medicine, the Alfred Hospital, Melbourne, Vic., Australia.; Central Clinical School, Monash University, Melbourne, Vic., Australia., Walters EH; School of Medicine, University of Tasmania, Hobart, TAS, Australia., Allen KJ; Murdoch Children's Research Institute, Melbourne, Vic., Australia., Erbas B; School of Public Health, La Trobe University, Melbourne, Vic., Australia., Perret JL; Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Vic., Australia.; Centre for Air quality and health Research and evaluation (CAR), Melbourne, Vic., Australia., Dharmage SC; Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Vic., Australia.; Murdoch Children's Research Institute, Melbourne, Vic., Australia., Lowe AJ; Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Vic., Australia.; Murdoch Children's Research Institute, Melbourne, Vic., Australia.
Jazyk: angličtina
Zdroj: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology [Clin Exp Allergy] 2019 Feb; Vol. 49 (2), pp. 171-179. Date of Electronic Publication: 2018 Sep 07.
DOI: 10.1111/cea.13251
Abstrakt: Background: Asthma and allergic diseases are heterogeneous. Measurement of biomarkers in exhaled breath condensate (EBC) may help to discriminate between different phenotypes and may assist with clinical prognostication.
Objectives: We aimed to assess associations between total nitric oxide products (NO x ) in EBC and different allergic phenotypes and lung function in young and middle-aged adults.
Methods: Cross-sectional analyses were nested within two Australian longitudinal studies, the Melbourne Atopy Cohort Study (MACS, mean age 17.8 years) and the Tasmanian Longitudinal Health Study (TAHS, mean age 49.4 years). Levels of EBC NO x were determined by Griess-reaction fluorescent method. Associations were assessed between EBC NO x and different allergic phenotypes, lung function and airway reactivity.
Results: Atopy, with or without asthma or rhinitis, was associated with increased EBC NO x levels particularly in individuals with poly-aero-sensitization. These findings were generally consistent across the two age groups. In the older cohort, use of ICS in the previous 12 months masked the association between sensitization and EBC NO x (OR = 0.64, 95% CI = 0.21-1.96, p for interaction = 0.05).
Conclusions and Clinical Relevance: In these population-based samples, EBC NO x was most strongly associated with atopic sensitization, rather than either current asthma or rhinitis, possibly indicating underlying increased airway inflammation associated with atopy. Therefore, EBC NO x could be a key predictor of atopy in both young and middle-aged adults, regardless of the presence of concomitant asthma or rhinitis.
(© 2018 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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