Safety and side-effect profile of intrathecal morphine in a diverse patient population undergoing total knee and hip arthroplasty.

Autor: Hess SR; Department of Orthopedics, Center for Orthopedic Research and Education, The CORE Institute, 18444 N. 25th Ave, Phoenix, AZ, 85023, USA. drshane33@gmail.com., Lahaye LA; Department of Anesthesiology, Virginia Commonwealth University, Richmond, VA, USA., Waligora AC; Greater Pittsburgh Orthopaedic Associates, Pittsburgh, PA, USA., Sima AP; Department of Biostatistics, Virginia Commonwealth University, Richmond, VA, USA., Jiranek WA; Duke University Medical Center, Durham, NC, USA., Golladay GJ; Department of Orthopaedic Surgery, Virginia Commonwealth University Medical Center, Richmond, VA, USA.
Jazyk: angličtina
Zdroj: European journal of orthopaedic surgery & traumatology : orthopedie traumatologie [Eur J Orthop Surg Traumatol] 2019 Jan; Vol. 29 (1), pp. 125-129. Date of Electronic Publication: 2018 Aug 13.
DOI: 10.1007/s00590-018-2293-9
Abstrakt: Intrathecal morphine (ITM) can be useful for postoperative analgesia following lower extremity joint arthroplasty, but concerns exist regarding potential dose-related side effects. In this study, we examined the safety and efficacy of ITM in patients undergoing lower extremity joint arthroplasty. We hypothesized that there would be (1) direct relationship between dosing and side effects, and (2) an inverse relationship between ITM dosing and 24-hour postoperative opioid requirement.
Databáze: MEDLINE
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