Promising synergistic activity of fluconazole with bioactive Guttiferone-A and derivatives against non-albicans Candida species.

Autor: Ribeiro de Carvalho R; Microbiology and Immunology Department, Federal University of Alfenas, 37130-000 Alfenas, Minas Gerais, Brazil., Chaves Silva N; Microbiology and Immunology Department, Federal University of Alfenas, 37130-000 Alfenas, Minas Gerais, Brazil., Cusinato M; Microbiology and Immunology Department, Federal University of Alfenas, 37130-000 Alfenas, Minas Gerais, Brazil., Tranches Dias KS; PeQuiM, Laboratory of Research in Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas, 37130-000 Alfenas, Minas Gerais, Brazil., Dos Santos MH; Department of Chemistry, Federal University of Viçosa, 36570-900 Viçosa, Minas Gerais, Brazil., Viegas Junior C; PeQuiM, Laboratory of Research in Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas, 37130-000 Alfenas, Minas Gerais, Brazil., Gonçalves Silva É; Secretaria de Educação do Estado de São Paulo, São Paulo, Brazil., Tranches Dias AL; Microbiology and Immunology Department, Federal University of Alfenas, 37130-000 Alfenas, Minas Gerais, Brazil. Electronic address: amandaltdias@gmail.com.
Jazyk: angličtina
Zdroj: Journal de mycologie medicale [J Mycol Med] 2018 Dec; Vol. 28 (4), pp. 645-650. Date of Electronic Publication: 2018 Aug 10.
DOI: 10.1016/j.mycmed.2018.07.006
Abstrakt: Natural products with diverse bioactivities and structures are an important source of novel chemicals with pharmaceutical potentials. Combinations of bioactive compounds with classical antimicrobial agents against drug-resistant or low-susceptible Candida spp. have been studied. Guttiferone-A and its derivatives were combined with fluconazole through the checkerboard method and tested against Candida spp. The results obtained, especially the Fractional Inhibitory Concentration Index (FICI) determined to the combinations, suggests promising results on the treatment of Candida infections, principally for species that present resistance or low antifungal susceptibility. The best result was seen for C. krusei, in which a synergic action of the association between fluconazole and Guttiferone-A resulted in a reduction of more than 100-fold in the alone inhibitory concentration (MIC) of fluconazole. Synergism was also noted in the association of fluconazole with the synthetic derivatives LFQM-79, LFQM-80 and LFQM-81 against C. glabrata, with reduction of up to four times in the alone IC of fluconazole. These results suggest the possibility of combined administration with reduction of doses and side effects of drugs conventionally used against Candida spp. and the promising therapeutic action of Guttiferone-A.
(Copyright © 2018. Published by Elsevier Masson SAS.)
Databáze: MEDLINE
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