Concentrations of oxidized linoleic acid derived lipid mediators in the amygdala and periaqueductal grey are reduced in a mouse model of chronic inflammatory pain.

Autor: Jensen JR; Lipid Mediators, Inflammation and Pain Unit, Laboratory of Clinical Investigation, National Institute on Aging, NIH, Baltimore, MD, United States., Pitcher MH; National Center for Complementary and Integrative Health, NIH, Bethesda, MD, United States., Yuan ZX; Lipid Mediators, Inflammation and Pain Unit, Laboratory of Clinical Investigation, National Institute on Aging, NIH, Baltimore, MD, United States., Ramsden CE; Lipid Mediators, Inflammation and Pain Unit, Laboratory of Clinical Investigation, National Institute on Aging, NIH, Baltimore, MD, United States; Intramural Program of the National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, United States., Domenichiello AF; Lipid Mediators, Inflammation and Pain Unit, Laboratory of Clinical Investigation, National Institute on Aging, NIH, Baltimore, MD, United States. Electronic address: Anthony.domenichiello@nih.gov.
Jazyk: angličtina
Zdroj: Prostaglandins, leukotrienes, and essential fatty acids [Prostaglandins Leukot Essent Fatty Acids] 2018 Aug; Vol. 135, pp. 128-136. Date of Electronic Publication: 2018 Jul 23.
DOI: 10.1016/j.plefa.2018.07.015
Abstrakt: Chronic pain is both a global public health concern and a serious source of personal suffering for which current treatments have limited efficacy. Recently, oxylipins derived from linoleic acid (LA), the most abundantly consumed polyunsaturated fatty acid in the modern diet, have been implicated as mediators of pain in the periphery and spinal cord. However, oxidized linoleic acid derived mediators (OXLAMs) remain understudied in the brain, particularly during pain states. In this study, we employed a mouse model of chronic inflammatory pain followed by a targeted lipidomic analysis of the animals' amygdala and periaqueductal grey (PAG) using LC-MS/MS to investigate the effect of chronic inflammatory pain on oxylipin concentrations in these two brain nuclei known to participate in pain sensation and perception. From punch biopsies of these brain nuclei, we detected twelve OXLAMs in both the PAG and amygdala and one arachidonic acid derived mediator, 15-HETE, in the amygdala only. In the amygdala, we observed an overall decrease in the concentration of the majority of OXLAMs detected, while in the PAG the concentrations of only the epoxide LA derived mediators, 9,10-EpOME and 12,13-EpOME, and one trihydroxy LA derived mediator, 9,10,11-TriHOME, were reduced. This data provides the first evidence that OXLAM concentrations in the brain are affected by chronic pain, suggesting that OXLAMs may be relevant to pain signaling and adaptation to chronic pain in pain circuits in the brain and that the current view of OXLAMs in nociception derived from studies in the periphery is incomplete.
(Published by Elsevier Ltd.)
Databáze: MEDLINE
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