Fatal disseminated cytomegalovirus infection with necrotizing oophoritis in a patient with acquired immunodeficiency syndrome.

Autor:	Soares LB; Emilio Ribas Institute of Infectious Diseases. São Paulo, SP, Brazil., Buccheri R; Emilio Ribas Institute of Infectious Diseases. São Paulo, SP, Brazil., Palhares RB; Emilio Ribas Institute of Infectious Diseases. São Paulo, SP, Brazil., Duarte-Neto AN; Universidade de São Paulo, Faculty of Medicine, Department of Anatomic Pathology, Emergency Department and LIM06. São Paulo, SP, Brazil.
Jazyk:	angličtina
Zdroj:	Autopsy & case reports [Autops Case Rep] 2018 Jul 30; Vol. 8 (3), pp. e2018029. Date of Electronic Publication: 2018 Jul 30 (Print Publication: 2018).
DOI:	10.4322/acr.2018.029
Abstrakt:	Disseminated human cytomegalovirus (CMV) disease occurs mainly as a congenital infection and among immunocompromised hosts. Patients with acquired immunodeficiency syndrome (AIDS) are at increased risk for CMV infection, and the most prevalent clinical manifestation is retinitis, followed by colitis, esophagitis, pneumonitis, and encephalitis. CMV oophoritis is poorly described in the literature with some cases reported in patients with hematological or solid malignancies, bone marrow or solid organ transplantation, immunosuppressive therapy, and advanced AIDS cases. We report the case of a 61-year-old woman with a recent diagnosis of AIDS, which was associated with a wasting syndrome. The patient presented with abdominal pain, headache, cutaneous vesicular lesions on the abdomen, anemia, lymphopenia, and hyponatremia; she died suddenly on the fourth day of hospitalization. The autopsy was performed and demonstrated disseminated CMV infection with hemorrhagic encephalitis as the immediate cause of death. Additionally, pneumonitis, extensive adrenalitis, ulcerated enteritis, focal hepatitis, and necrotizing oophoritis were found. Competing Interests: Conflict of interest: None
Databáze:	MEDLINE
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