Recent advances in canine leptospirosis: focus on vaccine development.
| Autor: | Eric Klaasen HL; Global Companion Animals Research and Development, Merck Sharp and Dohme Animal Health, Boxmeer, the Netherlands, eric.klaasen@merck.com., Adler B; Department of Microbiology, Monash University, Clayton, VIC, Australia. |
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| Jazyk: | angličtina |
| Zdroj: | Veterinary medicine (Auckland, N.Z.) [Vet Med (Auckl)] 2015 Jun 19; Vol. 6, pp. 245-260. Date of Electronic Publication: 2015 Jun 19 (Print Publication: 2015). |
| DOI: | 10.2147/VMRR.S59521 |
| Abstrakt: | Leptospirosis is a global infection of humans and animals caused by pathogenic Leptospira spp. Leptospirosis is a major zoonosis, with infection acquired from wild and domestic animals. It is also a significant cause of morbidity, mortality, and economic loss in production and companion animals. Leptospirosis in dogs is prevalent worldwide and as well as a cause of canine disease, it presents a zoonotic risk to human contacts. Canine leptospirosis does not differ greatly from the syndromes seen in other animal species, with hepatic, renal, and pulmonary involvement being the main manifestations. While the pathogenesis of disease is well documented at the whole animal level, the cellular and molecular basis remains obscure. Killed, whole-cell bacterin vaccines are licensed worldwide and have not changed greatly over the past several decades. Vaccine-induced immunity is restricted to serologically related serovars and is generally short-lived, necessitating annual revaccination. The appearance of new serovars as causes of canine leptospirosis requires constant epidemiological surveillance and tailoring of vaccines to cover emerging serovars. At the present time, there is no realistic prospect of alternative, non-bacterin vaccines in the foreseeable future. Competing Interests: Disclosure EK is an employee of, and BA has acted as an expert adviser to, Merck, Sharp and Dohme Animal Health. The authors report no other conflicts of interest in this work. |
| Databáze: | MEDLINE |
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